Tonino Bucciarelli

TL;DR: Vitamin E supplementation, metabolic control, and cyclooxygenase inhibitors were used to investigate the mechanisms of formation of the F2-isoprostane 8-iso-PGF2α in this setting.

TL;DR: It is concluded that the in vivo formation of the F2-isoprostane 8-epi-PGF2α is enhanced in the vast majority of patients with hypercholesterolemia and dose-dependent suppression of enhanced 8-Epi- PGF2 α formation by vitamin E supplementation may contribute to the beneficial effects of antioxidant treatment.

TL;DR: These findings establish a putative biochemical link between increased oxidant stress and aspirin-insensitive TX biosynthesis in patients with unstable angina and provide a rationale for dose-finding studies of antioxidants in this setting.

TL;DR: Altered oxidative processes leading to endothelial dysfunction and persistent platelet activation may contribute to increased soluble P-selectin levels, which may be proposed as a marker of endotocyte dysfunction in hypercholesterolemic patients.

TL;DR: Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome.