F
Facundo Ferrero Restelli
Researcher at University of Buenos Aires
Publications - 3
Citations - 4
Facundo Ferrero Restelli is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Tropomyosin receptor kinase A & Neurotrophin. The author has co-authored 2 publications.
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Journal ArticleDOI
Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis.
Facundo Ferrero Restelli,Paula Fontanet,Ana Paula De Vincenti,Tomás L. Falzone,Fernanda Ledda,Fernanda Ledda,Gustavo Paratcha +6 more
TL;DR: Tetraspanin1 (Tspan1) is identified as a critical regulator of TrkA signaling and neuronal differentiation induced by NGF, and knockdown of Tspan1 reduces the surface levels of TrKA by promoting its preferential sorting towards the autophagy/lysosomal degradation pathway.
Journal ArticleDOI
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
Ana Paula De Vincenti,Fernando Cruz Alsina,Facundo Ferrero Restelli,Håkan Hedman,Fernanda Ledda,Fernanda Ledda,Gustavo Paratcha +6 more
TL;DR: This article showed that Lrig1 and Lrig3 are co-expressed in Ret-positive mouse dorsal root ganglion (DRG) neurons and showed that deletion of either Lrig 1 or Lrig 3 significantly inhibited axonal growth.
Journal ArticleDOI
Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids
TL;DR: In this paper, the authors showed that DEX treatment promotes the transcription of Sprouty4, a regulatory molecule that is part of a negative feedback module that specifically abrogates Ras to Erk1/2 signaling in response to NGF.