F
Fernanda Ledda
Researcher at University of Buenos Aires
Publications - 33
Citations - 2780
Fernanda Ledda is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Neurotrophic factors. The author has an hindex of 22, co-authored 31 publications receiving 2548 citations. Previous affiliations of Fernanda Ledda include Fundación Instituto Leloir & National Scientific and Technical Research Council.
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Journal ArticleDOI
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.
TL;DR: The results uncover an unexpected intersection between short- and long-range mechanisms of intercellular communication and reveal a pathway for GDNF signaling that does not require the RET receptor.
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Released GFRα1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
Gustavo Paratcha,Fernanda Ledda,Louise Baars,Muriel Coulpier,Valerie Besset,Jonas Anders,Rizaldy P. Scott,Carlos F. Ibáñez +7 more
TL;DR: The results provide an explanation for the tissue distribution of GFRalpha1 and support the physiological importance of c-Ret activation in trans as a novel mechanism to potentiate and diversify the biological responses to GDNF.
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Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
Paul Berghuis,Marton B. Dobszay,Xinyu Wang,Sabrina M. Spano,Fernanda Ledda,Kyle M. Sousa,Gunnar Schulte,Patrik Ernfors,Ken Mackie,Gustavo Paratcha,Yasmin L. Hurd,Tibor Harkany +11 more
TL;DR: It is found that Src kinase-dependent TrkB receptor transactivation mediates endocannabinoid (eCB)-induced chemotaxis in the absence of BDNF, and eCBs suppress the BDNF-dependent morphogenesis of interneurons, and this suppression is abolished by SRC kinase inhibition in vitro.
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GDNF and GFRα: a versatile molecular complex for developing neurons
Gustavo Paratcha,Fernanda Ledda +1 more
TL;DR: Emerging evidence indicates a prominent role of GDNF and GFRalpha in the control of neuroblast migration and chemoattraction and in the formation of neuronal synapses by a new mechanism of ligand-induced cell adhesion, highlighting the importance of this versatile molecular complex for nervous system development, function and regeneration.
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The Expression of the Secreted Protein Acidic and Rich in Cysteine (SPARC) Is Associated with the Neoplastic Progression of Human Melanoma
TL;DR: In this article, the authors used western blot analysis to detect a single secreted 42-kDa band in human diploid fibroblasts-conditioned medium and a 45-to 40-kda doublet in the three melanoma cell lines and all the metastatic melanomas tested.