F
Fadi N Salloum
Researcher at Virginia Commonwealth University
Publications - 152
Citations - 8944
Fadi N Salloum is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cardioprotection & Reperfusion injury. The author has an hindex of 51, co-authored 137 publications receiving 8002 citations. Previous affiliations of Fadi N Salloum include VCU Medical Center.
Papers
More filters
Journal ArticleDOI
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
Eleonora Mezzaroma,Stefano Toldo,Daniela Farkas,Ignacio M. Seropian,Benjamin W. Van Tassell,Fadi N Salloum,Harsha Kannan,Angela C Menna,Norbert F. Voelkel,Antonio Abbate +9 more
TL;DR: The presence of the inflammasome in the mouse heart in an experimental mouse model of AMI as evidenced by increased caspase-1 activity and cytoplasmic aggregates of the three components of theInflammasomes may represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI.
Journal ArticleDOI
Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity
TL;DR: Prophylactic treatment with sildenafil prevented apoptosis and left ventricular dysfunction in a chronic model of doxorubicin-induced cardiomyopathy and significantly protected against doxorbicin cardiotoxicity; however, this protection was abolished by both L-NAME and 5-hydroxydecanoate.
Journal ArticleDOI
Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)
Antonio Abbate,Michael C. Kontos,John D. Grizzard,Giuseppe Biondi-Zoccai,Benjamin W. Van Tassell,Roshanak Robati,Lenore M. Roach,Ross Arena,Charlotte S. Roberts,Amit Varma,Christopher Gelwix,Fadi N Salloum,Hastillo A,Charles A. Dinarello,George W. Vetrovec +14 more
TL;DR: In this paper, the safety and effects of IL-1 blockade with anakinra on left ventricular (LV) remodeling after acute myocardial infarction (AMI) initiates an intense inflammatory response in which interleukin-1 plays a central role.
Journal ArticleDOI
Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction
Antonio Abbate,Fadi N Salloum,Elena Vecile,Anindita Das,Nicholas N Hoke,Stefania Straino,Giuseppe Biondi-Zoccai,Jon-Erik Houser,Ian Z Qureshi,Evan D. Ownby,Edoardo Gustini,Luigi M. Biasucci,Anna Severino,Maurizio C. Capogrossi,George W. Vetrovec,Filippo Crea,Alfonso Baldi,Rakesh C. Kukreja,Aldo Dobrina +18 more
TL;DR: Administration of anakinra within 24 hours of acute myocardial infarction significantly ameliorates the remodeling process by inhibiting cardiomyocyte apoptosis in 2 different experimental animal models of AMI.
Journal ArticleDOI
Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial KATP channels in rabbits
TL;DR: For the first time, it is demonstrated that sildenafil induces acute and delayed protective effects against ischemia-reperfusion injury, which are mediated by opening of mitochondrial K(ATP) channels.