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Antonio Abbate
Researcher at Virginia Commonwealth University
Publications - 512
Citations - 22477
Antonio Abbate is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 70, co-authored 507 publications receiving 17365 citations. Previous affiliations of Antonio Abbate include Università Campus Bio-Medico & MedStar Washington Hospital Center.
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Journal ArticleDOI
A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease.
Giuseppe Biondi-Zoccai,Marzia Lotrionte,Pierfrancesco Agostoni,Antonio Abbate,Massimiliano Fusaro,Francesco Burzotta,Luca Testa,Imad Sheiban,Giuseppe Sangiorgi +8 more
TL;DR: Non-compliance or withdrawal of aspirin treatment has ominous prognostic implication in subjects with or at moderate-to-high risk for CAD and aspirin discontinuation in such patients should be advocated only when bleeding risk clearly overwhelms that of atherothrombotic events.
Journal ArticleDOI
Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials.
Michael J. Lipinski,Giuseppe Biondi-Zoccai,Antonio Abbate,Reena Khianey,Imad Sheiban,Jozef Bartunek,Marc Vanderheyden,Hyo-Soo Kim,Hyun Jae Kang,Bodo E. Strauer,George W. Vetrovec +10 more
TL;DR: Meta-regression suggested the existence of a dose-response association between injected cell volume and LVEF change and support further multicenter randomized trials targeted to address the impact of intracoronary cell therapy on overall and event-free long-term survival.
Journal ArticleDOI
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
Eleonora Mezzaroma,Stefano Toldo,Daniela Farkas,Ignacio M. Seropian,Benjamin W. Van Tassell,Fadi N Salloum,Harsha Kannan,Angela C Menna,Norbert F. Voelkel,Antonio Abbate +9 more
TL;DR: The presence of the inflammasome in the mouse heart in an experimental mouse model of AMI as evidenced by increased caspase-1 activity and cytoplasmic aggregates of the three components of theInflammasomes may represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI.
Journal ArticleDOI
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19.
Aldo Bonaventura,Aldo Bonaventura,Alessandra Vecchié,Lorenzo Dagna,Kimberly Martinod,Dave L. Dixon,Benjamin W. Van Tassell,Francesco Dentali,Fabrizio Montecucco,Steffen Massberg,Marcel Levi,Antonio Abbate +11 more
TL;DR: In this paper, the authors proposed that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
Journal ArticleDOI
The NLRP3 inflammasome in acute myocardial infarction.
Stefano Toldo,Antonio Abbate +1 more
TL;DR: Evidence supporting the therapeutic value of NLRP3 inflammasome-targeted strategies in experimental models is summarized and the data supporting the role of the NLRP2 inflammaome in AMI and its consequences on adverse cardiac remodelling, cytokine-mediated systolic dysfunction, and heart failure are summarized.