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Ignacio M. Seropian
Researcher at Hospital Italiano de Buenos Aires
Publications - 47
Citations - 2192
Ignacio M. Seropian is an academic researcher from Hospital Italiano de Buenos Aires. The author has contributed to research in topics: Myocardial infarction & Heart failure. The author has an hindex of 20, co-authored 40 publications receiving 1804 citations. Previous affiliations of Ignacio M. Seropian include Virginia Commonwealth University.
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Journal ArticleDOI
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
Eleonora Mezzaroma,Stefano Toldo,Daniela Farkas,Ignacio M. Seropian,Benjamin W. Van Tassell,Fadi N Salloum,Harsha Kannan,Angela C Menna,Norbert F. Voelkel,Antonio Abbate +9 more
TL;DR: The presence of the inflammasome in the mouse heart in an experimental mouse model of AMI as evidenced by increased caspase-1 activity and cytoplasmic aggregates of the three components of theInflammasomes may represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI.
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Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction
TL;DR: The pathophysiological mechanisms of inflammation and ventricular remodeling after AMI are reviewed and the results of clinical trials with anti-inflammatory strategies are reviewed.
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Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure
Benjamin W. Van Tassell,Ross Arena,Stefano Toldo,Eleonora Mezzaroma,Tania Azam,Ignacio M. Seropian,Keyur B. Shah,Justin M. Canada,Norbert F. Voelkel,Charles A. Dinarello,Antonio Abbate +10 more
TL;DR: It is suggested that IL-1β activity contributes to poor exercise tolerance in patients with systolic HF and identifies IL- 1β blockade as a novel strategy for pharmacologic intervention.
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Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury.
Bernard J. Fisher,Ignacio M. Seropian,Donatas Kraskauskas,Jay N. Thakkar,Norbert F. Voelkel,Alpha A. Fowler,Ramesh Natarajan +6 more
TL;DR: Ascorbic acid administered in an interventional manner following lipopolysaccharide infusion attenuates proinflammatory, procoagulant states that induce lung vascular injury in an animal model of sepsis.
Journal ArticleDOI
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.
Stefano Toldo,Ignacio M. Seropian,Eleonora Mezzaroma,Benjamin W. Van Tassell,Fadi N Salloum,Eli C. Lewis,Norbert F. Voelkel,Charles A. Dinarello,Antonio Abbate +8 more
TL;DR: Exogenous administration of clinical grade AAT reduces caspase-1 activity in the ischemic myocardium leading to preservation of viableMyocardium and prevention of adverse cardiac remodeling.