F
Fangying Wang
Publications - 1
Citations - 47
Fangying Wang is an academic researcher. The author has contributed to research in topics: In vivo & Virus. The author has an hindex of 1, co-authored 1 publications receiving 47 citations.
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An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron
B.X. Quan,Huiping Shuai,Anjie Xia,Yuxin Hou,Rui Zeng,Xin-lei Liu,Guifeng Lin,Jingxin Qiao,Wen-Pei Li,Fangying Wang,Kai Wang,Renjie Zhou,Terrence Tsz-Tai Yuen,Mingxin Chen,Chaemin Yoon,Ming Wu,Shi-Yu Zhang,Chong Huang,Yifei Wang,Wei Yang,Chenyu Tian,Weimin Li,Yuxuan Wei,Kwok-Yung Yuen,Jasper Fuk-Woo Chan,Jian Lei,Hin Chu,Sheng-Hsiung Yang +27 more
TL;DR: In this article , a series of potent α-ketoamide-containing Mpro inhibitors were obtained using the Ugi four-component reaction and the prioritized compound, Y180, showed an IC50 of 8.1 nM against SARS-CoV-2 Mpro and had oral bioavailability of 92.9%, 31.9% and 85.7% in mice, rats and dogs, respectively.