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Xin-lei Liu
Researcher at Beijing University of Technology
Publications - 4
Citations - 59
Xin-lei Liu is an academic researcher from Beijing University of Technology. The author has contributed to research in topics: Immunogenicity & Group-specific antigen. The author has an hindex of 1, co-authored 2 publications receiving 2 citations.
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Journal ArticleDOI
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron
B.X. Quan,Huiping Shuai,Anjie Xia,Yuxin Hou,Rui Zeng,Xin-lei Liu,Guifeng Lin,Jingxin Qiao,Wen-Pei Li,Fangying Wang,Kai Wang,Renjie Zhou,Terrence Tsz-Tai Yuen,Mingxin Chen,Chaemin Yoon,Ming Wu,Shi-Yu Zhang,Chong Huang,Yifei Wang,Wei Yang,Chenyu Tian,Weimin Li,Yuxuan Wei,Kwok-Yung Yuen,Jasper Fuk-Woo Chan,Jian Lei,Hin Chu,Sheng-Hsiung Yang +27 more
TL;DR: In this article , a series of potent α-ketoamide-containing Mpro inhibitors were obtained using the Ugi four-component reaction and the prioritized compound, Y180, showed an IC50 of 8.1 nM against SARS-CoV-2 Mpro and had oral bioavailability of 92.9%, 31.9% and 85.7% in mice, rats and dogs, respectively.
Journal ArticleDOI
Rapid testing for coronavirus disease 2019 (COVID-19)
TL;DR: In this paper , a connection is made from the normal COVID-19 immune response to the design and efficacy of rapid testing, which stands out amongst peer platforms due to its cost-effective design, user-friendly interface and low sample-to-readout times.
Journal Article
[Codon modification of HIV-1 subtype B gag gene and its immunogenicity in mice].
TL;DR: The codon modification of gag gene is successful and the recombinant adenovirus vaccine harbouring mod.
[Immunogenicity of a chimeric adenovirus type 5 vector with type 35 fiber containing HIV-1 gag in mice].
Xin-lei Liu,Shuang-Qing Yu,Xia Feng,Xiao-li Wang,Hong-mei Liu,Xiao-mei Zhang,Hong-Xia Li,Ling Zhou,Li Zelin,Yi Zheng +9 more
TL;DR: The results indicated that fiber exchange alone does not evade pre-existing Ad5 immunity, and the rAd5/F35-mod.gag vector can elicit specific CTL response and IgG antibody in animal model.