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Sheng-Hsiung Yang
Researcher at Mackay Memorial Hospital
Publications - 23
Citations - 165
Sheng-Hsiung Yang is an academic researcher from Mackay Memorial Hospital. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 1 citations.
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Journal ArticleDOI
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron
B.X. Quan,Huiping Shuai,Anjie Xia,Yuxin Hou,Rui Zeng,Xin-lei Liu,Guifeng Lin,Jingxin Qiao,Wen-Pei Li,Fangying Wang,Kai Wang,Renjie Zhou,Terrence Tsz-Tai Yuen,Mingxin Chen,Chaemin Yoon,Ming Wu,Shi-Yu Zhang,Chong Huang,Yifei Wang,Wei Yang,Chenyu Tian,Weimin Li,Yuxuan Wei,Kwok-Yung Yuen,Jasper Fuk-Woo Chan,Jian Lei,Hin Chu,Sheng-Hsiung Yang +27 more
TL;DR: In this article , a series of potent α-ketoamide-containing Mpro inhibitors were obtained using the Ugi four-component reaction and the prioritized compound, Y180, showed an IC50 of 8.1 nM against SARS-CoV-2 Mpro and had oral bioavailability of 92.9%, 31.9% and 85.7% in mice, rats and dogs, respectively.
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KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming
Feifei Na,Xiangyu Pan,Jingyao Chen,Xuelan Chen,Manli Wang,Pengliang Chi,Liting You,Lan Zhang,Ailing Zhong,Lei Zhao,Siqi Dai,Mengsha Zhang,Yiyun Wang,Bo Wang,Jianan Zheng,Yuying Wang,Jing Xu,Jian Wang,Baohong Wu,Mei Chen,Songyu Liu,Jianxin Xie,Meijuan Huang,Youling Gong,Jianguo Zhu,Lin Zhou,Yan Zhang,Min Yu,Panwen Tian,Mingyu Fan,Zhenghao Lu,Zhihong Xue,Yinglan Zhao,Hanshuo Yang,Chengjian Zhao,Yan Wang,Junhong Han,Sheng-Hsiung Yang,Dan Xie,Luyu Chen,Qian Zhong,Mu Sheng Zeng,Scott W. Lowe,You Lu,Yu Liu,Yuquan Wei,Cheng Chen +46 more
TL;DR: In this paper , the authors found that a deficiency of KMT2C, a histone H3 lysine 4 methyltransferase frequently mutated in extensive-stage SCLC, promoted multiple-organ metastases in mice.
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Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
Xin Yang,Xuehui Wang,Zheng Xu,Chao Wu,Yangli Zhou,Yifei Wang,Guifeng Lin,Kan Li,Ming Wu,Anjie Xia,Jingming Liu,Lin Cheng,Jun Zou,Wei Yan,Zhenhua Shao,Sheng-Hsiung Yang +15 more
TL;DR: The crystallographic and cryo-EM structures of CB1 bound to the positive allosteric modulator ZCZ011 revealallosteric modulation ofCB1 by rearrangement of the TM2 and TM3 transmembrane domains.
Journal ArticleDOI
HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing
Nan Liu,Lifang Zhou,Guifeng Lin,Yun Hu,Yaoge Jiao,Yanhong Wang,Jingming Liu,Sheng-Hsiung Yang,Shaohua Yao +8 more
TL;DR: In this paper , a small fragment was integrated into the genome by prime editing (PE) and a group of histone deacetylase inhibitors (HDACi) was identified, which increased the efficiency of both cytosine base editing (CBE) and ABE.
Journal ArticleDOI
Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.
Yanqin Jiao,Jinshan Nan,Bo Mu,Yun Zhang,Nenghua Zhou,Shunhua Yang,Shanshan Zhang,Wan-Ting Lin,Falu Wang,Anjie Xia,Zhi-Xing Cao,Pei Fei Chen,Zhiling Pan,Guifeng Lin,Shulei Pan,H. Bin,Linli Li,Sheng-Hsiung Yang +17 more
TL;DR: In this paper , the authors conducted a phenotypic screening against NLRP3-dependent pyroptosis and discovered the hit compound 1, which showed moderate antipyroptotic activity.