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Chong Huang
Researcher at Sichuan University
Publications - 9
Citations - 333
Chong Huang is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 2 publications receiving 81 citations.
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Journal ArticleDOI
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
Jingxin Qiao,Y. Li,Rui Zeng,Feng-Liang Liu,Rong-Hua Luo,Chong Huang,Yifei Wang,Jie Zhang,Baoxue Quan,Chenjian Shen,Xin Mao,Xinlei Liu,Weining Sun,Wei Yang,Xincheng Ni,Kai Wang,Ling Xu,Zilei Duan,Qing-Cui Zou,Hai-Lin Zhang,Qu Wang,Yang-Hao-Peng Long,Ming-Hua Li,Rui-Cheng Yang,Xiaolong Liu,Jing You,Yangli Zhou,Rui Yao,Wen-Pei Li,Jing-Ming Liu,Pei Chen,Yang Liu,Guifeng Lin,Xin Yang,Jun Zou,Lin-Li Li,Yiguo Hu,Guangwen Lu,Weimin Li,Yuquan Wei,Yong-Tang Zheng,Jian Lei,Shengyong Yang +42 more
TL;DR: In this article, the main protease (Mprotease) of SARS-CoV-2 plays a central role in viral replication, and 32 bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir were designed and synthesized.
Journal ArticleDOI
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron
B.X. Quan,Huiping Shuai,Anjie Xia,Yuxin Hou,Rui Zeng,Xin-lei Liu,Guifeng Lin,Jingxin Qiao,Wen-Pei Li,Fangying Wang,Kai Wang,Renjie Zhou,Terrence Tsz-Tai Yuen,Mingxin Chen,Chaemin Yoon,Ming Wu,Shi-Yu Zhang,Chong Huang,Yifei Wang,Wei Yang,Chenyu Tian,Weimin Li,Yuxuan Wei,Kwok-Yung Yuen,Jasper Fuk-Woo Chan,Jian Lei,Hin Chu,Sheng-Hsiung Yang +27 more
TL;DR: In this article , a series of potent α-ketoamide-containing Mpro inhibitors were obtained using the Ugi four-component reaction and the prioritized compound, Y180, showed an IC50 of 8.1 nM against SARS-CoV-2 Mpro and had oral bioavailability of 92.9%, 31.9% and 85.7% in mice, rats and dogs, respectively.
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Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors
TL;DR: The discovery of a new series of PB2 inhibitors containing the skeleton 5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one provides a promising lead compound for subsequent anti-influenza drug discovery targeting PB2.
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Non-classical ferroptosis inhibition by a small molecule targeting PHB2
Wei Yang,Bo Mu,Jingsong You,Chenyu Tian,H. Bin,Zhiqiang Xu,Liting Zhang,Ronggang Ma,Ming Wu,Guo Zhang,Chong Huang,Linli Li,Zhenhua Shao,Lunzhi Dai,Laurent Désaubry,Sheng-Hsiung Yang +15 more
TL;DR: Li et al. as mentioned in this paper reported a new ferroptosis inhibitor, termed YL-939, which is neither an antioxidant nor an iron-chelator, and revealed a new regulation mechanism of FerroPTosis.
Journal ArticleDOI
Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects.
Yueshan Li,Liting Zhang,Ruicheng Yang,Zeen Qiao,Ming Wu,Chong Huang,Chenyu Tian,Xin-Mei Luo,Wei Yang,Yun-Ni Zhang,Linli Li,Shengyong Yang +11 more
TL;DR: Structural-activity relationship analyses led to the identification of a number of potent TNIK inhibitors with compound 21k being the most active one and displaying excellent selectivity for TNIK against 406 other kinases.