F
Faraaz B. Chekeni
Researcher at University of Virginia
Publications - 5
Citations - 2744
Faraaz B. Chekeni is an academic researcher from University of Virginia. The author has contributed to research in topics: Pannexin & Apoptosis. The author has an hindex of 5, co-authored 5 publications receiving 2352 citations. Previous affiliations of Faraaz B. Chekeni include Carter Center.
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Journal ArticleDOI
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott,Faraaz B. Chekeni,Paul C. Trampont,Eduardo R. Lazarowski,Alexandra Kadl,Scott F. Walk,Daeho Park,Robin I. Woodson,Marina Ostankovich,Poonam Sharma,Jeffrey J. Lysiak,T. Kendall Harden,Norbert Leitinger,Kodi S. Ravichandran,Kodi S. Ravichandran +14 more
TL;DR: Nucleotides are identified as a critical find-me cue released by apoptotic cells to promote P2Y2-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find- me signal and efficient corpse clearance in vivo.
Journal ArticleDOI
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Faraaz B. Chekeni,Michael R. Elliott,Michael R. Elliott,Joanna K. Sandilos,Scott F. Walk,Scott F. Walk,Jason M. Kinchen,Jason M. Kinchen,Eduardo R. Lazarowski,Allison Armstrong,Allison Armstrong,Silvia Penuela,Dale W. Laird,Guy S. Salvesen,Brant E. Isakson,Douglas A. Bayliss,Kodi S. Ravichandran,Kodi S. Ravichandran +17 more
TL;DR: PANX1 is identified as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases is identified.
Journal ArticleDOI
Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region
Joanna K. Sandilos,Yu-Hsin Chiu,Faraaz B. Chekeni,Allison Armstrong,Scott F. Walk,Kodi S. Ravichandran,Douglas A. Bayliss +6 more
TL;DR: Evidence is provided suggesting that the C terminus interacts with the human PANX1 (hPANX1) pore and that cleavage-mediated channel activation requires disruption of this inhibitory interaction, and it is shown that relief of inhibition following cleavage requires dissociation of the C Terminus from the channel pore.
Journal ArticleDOI
Pannexin1 Regulates α1-Adrenergic Receptor–Mediated Vasoconstriction
Marie Billaud,Alexander W. Lohman,Adam C. Straub,Robin Looft-Wilson,Scott R. Johnstone,Christina A. Araj,Angela K. Best,Faraaz B. Chekeni,Kodi S. Ravichandran,Silvia Penuela,Dale W. Laird,Brant E. Isakson +11 more
TL;DR: In this paper, the role of pannexins in phenylephrine- and KCl-mediated constriction of resistance arteries was investigated, and it was shown that Pannexins are purine-releasing channels permeable to the vasoconstrictor ATP.
Journal ArticleDOI
The role of nucleotides in apoptotic cell clearance: implications for disease pathogenesis.
TL;DR: The role of nucleotides in the apoptotic cell clearance process is reviewed and their implications for disease pathogenesis are discussed.