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Alexander W. Lohman
Researcher at University of Calgary
Publications - 34
Citations - 2136
Alexander W. Lohman is an academic researcher from University of Calgary. The author has contributed to research in topics: Pannexin & Purinergic signalling. The author has an hindex of 18, co-authored 33 publications receiving 1705 citations. Previous affiliations of Alexander W. Lohman include University of Missouri & University of Virginia.
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Journal ArticleDOI
Mechanisms of ATP release and signalling in the blood vessel wall
TL;DR: The aim of this review is to examine the current proposed mechanisms of ATP release from vascular cells, with a special emphasis on the transporters and channels involved in ATPRelease from vascular smooth muscle cells, endothelial cells, circulating red blood cells, and perivascular sympathetic nerves.
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Endothelial cell expression of haemoglobin α regulates nitric oxide signalling
Adam C. Straub,Alexander W. Lohman,Marie Billaud,Scott R. Johnstone,Scott Dwyer,Monica Y. Lee,Pamela D. Schoppee Bortz,Angela K. Best,Linda Columbus,Benjamin Gaston,Brant E. Isakson +10 more
TL;DR: It is reported that haemoglobin (Hb) α is expressed in human and mouse arterial endothelial cells and enriched at the myoendothelial junction, where it regulates the effects of NO on vascular reactivity, revealing a new mechanism by which the regulation of the intracellular Hb α oxidation state controls NOS signalling in non-erythroid cells.
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Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity
Nicholas L. Weilinger,Alexander W. Lohman,Brooke D. Rakai,Evelyn M M Ma,Jennifer Bialecki,Valentyna Maslieieva,Travis Rilea,Mischa V Bandet,Nathan T Ikuta,Lucas Scott,Michael A. Colicos,G. Campbell Teskey,Ian R. Winship,Roger J. Thompson +13 more
TL;DR: It is reported that NMDARs signal during ligand binding without activation of their ion conduction pore, providing insights into a new signaling modality of N MDARs that has broad-reaching implications for brain physiology and pathology.
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Differentiating connexin hemichannels and pannexin channels in cellular ATP release
TL;DR: Differentiating the distinct signaling pathways that regulate these two channels will advance the current knowledge of cellular communication and aid in the development of novel rationally‐designed drugs for modulation of Panx and Cx activity, respectively.
Journal ArticleDOI
Pannexin1 Regulates α1-Adrenergic Receptor–Mediated Vasoconstriction
Marie Billaud,Alexander W. Lohman,Adam C. Straub,Robin Looft-Wilson,Scott R. Johnstone,Christina A. Araj,Angela K. Best,Faraaz B. Chekeni,Kodi S. Ravichandran,Silvia Penuela,Dale W. Laird,Brant E. Isakson +11 more
TL;DR: In this paper, the role of pannexins in phenylephrine- and KCl-mediated constriction of resistance arteries was investigated, and it was shown that Pannexins are purine-releasing channels permeable to the vasoconstrictor ATP.