F
Farooq Rahman
Researcher at University College London Hospitals NHS Foundation Trust
Publications - 67
Citations - 2088
Farooq Rahman is an academic researcher from University College London Hospitals NHS Foundation Trust. The author has contributed to research in topics: Parenteral nutrition & Crohn's disease. The author has an hindex of 20, co-authored 60 publications receiving 1772 citations. Previous affiliations of Farooq Rahman include University College Hospital & University College London.
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Journal ArticleDOI
Incidence and Severity of Prepouch Ileitis: A Distinct Disease Entity or a Manifestation of Refractory Pouchitis?
Mark A Samaan,Djuna C. de Jong,Saloomeh Sahami,S Morgan,Konstantinos C. Fragkos,Sharmila Subramaniam,Klaartje Kok,Jesica Makanyanga,I Barnova,Hajeena Saravanapavan,I Parisi,Simona Di Caro,Roser Vega,Farooq Rahman,Sara McCartney,Stuart Bloom,Gijs R. van den Brink,Mark Löwenberg,Cyriel Y. Ponsioen,Christianne J. Buskens,Pieter J. Tanis,Anthony de Buck van Overstraeten,Andre DʼHoore,Willem A. Bemelman,Geert DʼHaens +24 more
TL;DR: Once PI is diagnosed, clinicians should be aware that response to antibiotic therapy is less likely than in pouchitis alone and immunomodulatory therapy and escalation to anti–tumor necrosis factor agents should be considered early in cases of nonresponse.
Journal ArticleDOI
Performance Status, Prognostic Scoring, and Parenteral Nutrition Requirements Predict Survival in Patients with Advanced Cancer Receiving Home Parenteral Nutrition.
N. Keane,Konstantinos C. Fragkos,P.S. Patel,Friderike Bertsch,Shameer Mehta,Simona Di Caro,Farooq Rahman +6 more
TL;DR: Performer status, prognostic scoring, and PN requirements may predict survival in patients with advanced cancer receiving HPN, and survival was not significantly affected by the presence of metastatic disease, previous or concurrent surgery, chemo-radiotherapy, or indication.
Journal ArticleDOI
Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci.
Gavin W. Sewell,Farooq Rahman,Farooq Rahman,Adam P. Levine,Luke Jostins,Philip J. Smith,Ann P. Walker,Stuart Bloom,Anthony W. Segal,Andrew M. Smith +9 more
TL;DR: This study supports the hypothesis of defective proinflammatory cytokine secretion and an innate immunodeficiency in CD, which is evident downstream of multiple TLRs, affects all disease phenotypes, and is unrelated to 34 polymorphisms associated with CD by GWAS.
Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4.
TL;DR: A dysregulated innate immune response with over-expression of molecules associated with leukocyte recruitment and activation that may eventuate in the hallmark chronic immune-mediated inflammation of UC is highlighted.
Journal ArticleDOI
Diminished Macrophage Apoptosis and Reactive Oxygen Species Generation after Phorbol Ester Stimulation in Crohn's Disease
Christine D. Palmer,Farooq Rahman,Farooq Rahman,Gavin W. Sewell,Afshan Ahmed,Margaret Ashcroft,Stuart Bloom,Anthony W. Segal,Andrew Smith +8 more
TL;DR: These findings add to a growing body of evidence highlighting disordered macrophage function in CD and, given their pivotal role in orchestrating inflammatory responses, defective apoptosis could potentially contribute to the pathogenesis of CD.