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Andrew M. Smith
Researcher at University College London
Publications - 82
Citations - 3776
Andrew M. Smith is an academic researcher from University College London. The author has contributed to research in topics: Inflammation & Innate immune system. The author has an hindex of 28, co-authored 81 publications receiving 3373 citations. Previous affiliations of Andrew M. Smith include London Research Institute & UCL Eastman Dental Institute.
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Journal ArticleDOI
Reversal of the TCR stop signal by CTLA-4.
Helga Schneider,Helga Schneider,Jos Downey,Andrew M. Smith,Bernd H. Zinselmeyer,Bernd H. Zinselmeyer,Catherine M. Rush,Catherine M. Rush,James M. Brewer,James M. Brewer,Bin Wei,Nancy Hogg,Paul Garside,Paul Garside,Christopher E. Rudd,Christopher E. Rudd +15 more
TL;DR: It is shown that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells, which suggests a fundamentally different model of reverse stop signaling.
Journal ArticleDOI
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
Andrew M. Smith,Farooq Rahman,Bu’Hussain Hayee,Simon J Graham,Daniel Marks,Gavin W. Sewell,Christine D. Palmer,Jonathan I. Wilde,Brian M. J. Foxwell,Israel S. Gloger,Trevor J. Sweeting,Mark Marsh,Ann P. Walker,Stuart Bloom,Anthony W. Segal +14 more
TL;DR: It is suggested that in CD macrophages, an abnormal proportion of cytokines are routed to lysosomes and degraded rather than being released through the normal secretory pathway, which indicates accelerated intracellular breakdown.
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LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment
TL;DR: This study analyzes signaling events initiated through binding of the leukocyte integrin LFA-1 to ICAM-1, which leads to T cell attachment, polarization and random migration, finding that the activity of these two kinases is spatially segregated.
Journal ArticleDOI
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
Andrew M. Smith,Yolanda R. Carrasco,Paula Stanley,Nelly Kieffer,Facundo D. Batista,Nancy Hogg +5 more
TL;DR: This work has investigated the distribution, activity, and cytoskeletal linkage of the integrin lymphocyte function associated antigen-1 (LFA-1) on human T lymphocytes migrating on endothelial cells and on ligand intercellular adhesion molecule- 1 (ICAM-1).
Journal ArticleDOI
The role of the integrin LFA-1 in T-lymphocyte migration.
TL;DR: It is speculated that T cells have evolved a mode of rapid migration that is of paramount importance in achieving the high‐speed immune surveillance upon which depends the body’s protection against diverse invaders from pathogens to cancer cells.