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Anthony W. Segal
Researcher at University College London
Publications - 281
Citations - 24497
Anthony W. Segal is an academic researcher from University College London. The author has contributed to research in topics: NADPH oxidase & Oxidase test. The author has an hindex of 80, co-authored 279 publications receiving 23402 citations. Previous affiliations of Anthony W. Segal include Utrecht University & Northwick Park Hospital.
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Journal ArticleDOI
How neutrophils kill microbes
TL;DR: Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase, but this is incorrect.
Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
Journal ArticleDOI
Killing activity of neutrophils is mediated through activation of proteases by K + flux
Emer P. Reeves,Hui Lu,Hugues Lortat Jacobs,Carlo Messina,Steve Bolsover,Giorgio Gabella,Eric O. Potma,Alice Warley,Jürgen Roes,Anthony W. Segal +9 more
TL;DR: It is shown that mice made deficient in neutrophil-granule proteases but normal in respect of superoxide production and iodinating capacity, are unable to resist staphylococcal and candidal infections.
Journal ArticleDOI
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
TL;DR: The active components of purified ω1 are two proteins that associate as heterodimers17, and here it is reported that these are the small GTP-binding protein p21racl and the GDP-dissociation inhibitor rhoGDI.
Journal ArticleDOI
The biochemical basis of the NADPH oxidase of phagocytes
Anthony W. Segal,Arie Abo +1 more
TL;DR: The NADPH oxidase is an electron transport chain found in lymphocytes and in the wall of the endocytic vacuole of 'professional' phagocytic cells and provides a key to the understanding of the way in which these GTP-binding proteins function.