M
Mark A Samaan
Researcher at Guy's and St Thomas' NHS Foundation Trust
Publications - 88
Citations - 2761
Mark A Samaan is an academic researcher from Guy's and St Thomas' NHS Foundation Trust. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 64 publications receiving 2031 citations. Previous affiliations of Mark A Samaan include University of Amsterdam & University College Hospital.
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Journal ArticleDOI
Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.
Laurent Peyrin-Biroulet,William J. Sandborn,Bruce E. Sands,Walter Reinisch,Walter Reinisch,Willem A. Bemelman,Robert V Bryant,G R D’Haens,Iris Dotan,Marla Dubinsky,Brian G. Feagan,Gionata Fiorino,Richard B. Gearry,S. Krishnareddy,Peter L. Lakatos,Edward V. Loftus,P. Marteau,Pia Munkholm,Travis B. Murdoch,Ingrid Ordás,Remo Panaccione,Robert H. Riddell,J. Ruel,David T. Rubin,Mark A Samaan,Corey A. Siegel,Mark S. Silverberg,Jaap Stoker,Stefan Schreiber,Simon Travis,G. Van Assche,G. Van Assche,Silvio Danese,Julián Panés,Guillaume Bouguen,Sarah O’Donnell,Benjamin Pariente,S. Winer,Stephen B. Hanauer,J.-F. Colombel +39 more
TL;DR: Evidence- and consensus-based recommendations for selecting the goals for treat-to-target strategies in patients with IBD are made available and future studies are needed to determine how these targets will change disease course and patients’ quality of life.
Journal ArticleDOI
Development and validation of a histological index for UC
Mahmoud Mosli,Mahmoud Mosli,Brian G. Feagan,Guangyong Zou,William J. Sandborn,William J. Sandborn,Geert D'Haens,Reena Khanna,Lisa M. Shackelton,Christopher W Walker,Sigrid Nelson,Margaret K. Vandervoort,Valerie Frisbie,Mark A Samaan,Vipul Jairath,Vipul Jairath,David K. Driman,Karel Geboes,Mark A. Valasek,Rish K. Pai,Gregory Y. Lauwers,Robert H. Riddell,Larry Stitt,Barrett G. Levesque,Barrett G. Levesque +24 more
TL;DR: The RHI is a new histopathological index with favourable operating properties and is evaluated by analyses of change scores, standardised effect size (SES) and Guyatt's responsiveness statistic (GRS) using data from a clinical trial of an effective therapy.
Journal ArticleDOI
Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis
Nadia Mohammed Vashist,Mark A Samaan,Mahmoud Mosli,Claire E Parker,John K MacDonald,John K MacDonald,Sigrid Nelson,Guangyong Zou,Guangyong Zou,Brian G. Feagan,Brian G. Feagan,Reena Khanna,Vipul Jairath +12 more
TL;DR: A systematic review was undertaken to identify and evaluate the development and operating characteristics of histologic disease activity indices used to assess disease activity in people with ulcerative colitis and found the Nancy Index and the Robarts Histopathology Index have undergone the most validation.
Journal ArticleDOI
A systematic review of the measurement of endoscopic healing in ulcerative colitis clinical trials: recommendations and implications for future research.
Mark A Samaan,Mahmoud Mosli,William J. Sandborn,Brian G. Feagan,Geert DʼHaens,Elena Dubcenco,Kenneth A. Baker,Barrett G. Levesque +7 more
TL;DR: Both the endoscopic evaluative instrument selected and the definition chosen for mucosal healing affect the validity of assessing endoscopic disease activity during a clinical trial for UC.
Journal ArticleDOI
Reproducibility of histological assessments of disease activity in UC
Mahmoud Mosli,Brian G. Feagan,Brian G. Feagan,Guangyong Zou,Guangyong Zou,William J. Sandborn,William J. Sandborn,Geert D'Haens,Geert D'Haens,Reena Khanna,Reena Khanna,Cynthia Behling,Keith J. Kaplan,David K. Driman,Lisa M. Shackelton,Kenneth A. Baker,John K MacDonald,Margaret K. Vandervoort,Mark A Samaan,Karel Geboes,Mark A. Valasek,Rish K. Pai,Cord Langner,Robert H. Riddell,Robert H. Riddell,Noam Harpaz,Maida J. Sewitch,Michael R. Peterson,Larry Stitt,Barrett G. Levesque,Barrett G. Levesque +30 more
TL;DR: According to the consensus process results, standardisation of item definitions and modification of the existing indices is required to create an optimal UC histological instrument.