F
Farshad Niazi
Researcher at Case Western Reserve University
Publications - 9
Citations - 568
Farshad Niazi is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: PTEN & Long non-coding RNA. The author has an hindex of 6, co-authored 9 publications receiving 488 citations. Previous affiliations of Farshad Niazi include Cleveland Clinic Lerner Research Institute & Cleveland Clinic.
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Journal ArticleDOI
Negative regulation of the interferon response by an interferon-induced long non-coding RNA
Hiroto Kambara,Farshad Niazi,Lenche Kostadinova,Dilip Moonka,Christopher T. Siegel,Anthony B. Post,Elena Carnero,Marina Barriocanal,Puri Fortes,Donald D. Anthony,Saba Valadkhan +10 more
TL;DR: Results indicate that the IFN response involves a lncRNA-mediated negative regulatory mechanism, and lnc RNA-CMPK2 was strongly upregulated in a subset of HCV-infected human livers, suggesting a role in modulation of theIFN response in vivo.
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Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3′ UTRs
Farshad Niazi,Saba Valadkhan +1 more
TL;DR: Interestingly, analyses revealed significant similarities between the lncRNAs and the 3' untranslated regions (3' UTRs) in protein-coding RNAs in structural features and sequence composition, which indicates that highly similar evolutionary constraints govern the function of regulatory RNA sequences in the cell.
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A Novel RNA Motif Mediates the Strict Nuclear Localization of a Long Noncoding RNA
Bing Zhang,Lalith Gunawardane,Farshad Niazi,Fereshteh Kenari Jahanbani,Xin Chen,Saba Valadkhan +5 more
TL;DR: In this paper, the authors analyzed the sequence requirements for nuclear localization in an intergenic lncRNA named BORG (BMP2-OP1-responsive gene), which is both spliced and polyadenylated but is strictly localized in nuclei.
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Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder
Amanda K. Tilot,Amanda K. Tilot,Amanda K. Tilot,Gurkan Bebek,Gurkan Bebek,Gurkan Bebek,Farshad Niazi,Farshad Niazi,Jessica Altemus,Jessica Altemus,Todd Romigh,Todd Romigh,Thomas W. Frazier,Charis Eng +13 more
TL;DR: Observations suggest that the Ptenm3m4 model recapitulates multiple molecular features of human ASD, and that Pten operates far upstream of common pathways within ASD pathogenesis.
Journal ArticleDOI
Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas.
Joanne Ngeow,Wanfeng Yu,Wanfeng Yu,Lamis Yehia,Lamis Yehia,Farshad Niazi,Farshad Niazi,Jinlian Chen,Jinlian Chen,Xuhua Tang,Brandie Heald,Brandie Heald,Junying Lei,Junying Lei,Todd Romigh,Todd Romigh,Lisa Tucker-Kellogg,Kiat Hon Lim,Haiwei Song,Charis Eng +19 more
TL;DR: A unique case of familial juvenile polyposis syndrome associated with gastrointestinal ganglioneuromas of unknown etiology is presented and a new susceptibility locus for HPS is identified.