F
Faustino Mollinedo
Researcher at Spanish National Research Council
Publications - 231
Citations - 21625
Faustino Mollinedo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Edelfosine & Apoptosis. The author has an hindex of 56, co-authored 228 publications receiving 18565 citations. Previous affiliations of Faustino Mollinedo include University of Salamanca & University of Valladolid.
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Journal ArticleDOI
Edelfosine is incorporated into rafts and alters their organization.
Alessio Ausili,Alejandro Torrecillas,Francisco J. Aranda,Faustino Mollinedo,Consuelo Gajate,Senena Corbalán-García,Ana de Godos,Juan C. Gómez-Fernández +7 more
TL;DR: Cell experiments showed that edelfosine colocalizes in vivo with rafts and that it may reach concentrations higher than 20 mol % of total lipid, indicating that the concentrations used in the biophysical experiments were within what can be expected in a cell membrane.
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Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation.
TL;DR: The capacity of human neutrophils to release arachidonic acid from diacylglycerol was increased and the translocation from the membrane of gelatinase-containing granules to the plasma membrane may play an important role in regulating the diACYlglycersol level in stimulated human neutophils.
Journal Article
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
TL;DR: Aplidine is an extremely potent and rapid apoptotic inducer on leukemic cells that triggers Fas/CD95- and mitochondrial-mediated apoptotic signaling routes, and shows a rather selective apoptotic action on cancer cells and activated T cells.
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Inhibition of N‐linked glycosylation induces early apoptosis in human promyelocytic HL‐60 cells
TL;DR: The observations indicate that the main effect of tunicamycin in HL‐60 cells is the induction of apoptosis, and inhibitors of RNA and protein synthesis displayed a protective effect.
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Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum
Consuelo Gajate,Marcia Matos-da-Silva,El Habib Dakir,Rosalba I. Fonteriz,Javier Alvarez,Faustino Mollinedo +5 more
TL;DR: The results suggest that edelfosine exerts its pro-apoptotic action in pancreatic cancer cells, both in vitro and in vivo, through its accumulation in the ER, which leads to ER stress and apoptosis.