Dolores Pérez-Sala

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: New oxidative modifications in Cys62 involved in the redox regulation of the NF-kappaB subunit p50 are identified and could represent a molecular basis for the coupling of pro-oxidative stimuli to gene expression.

TL;DR: Results clearly show that p50 is a target for covalent modification by 15d-PGJ2 that results in inhibition of DNA binding.

TL;DR: A mechanism for the activation of the Ras signaling pathway is described, which results from the chemical modification of H-Ras by formation of a covalent adduct with cyclopentenone prostaglandins.

TL;DR: It is shown that 15d-PGJ2 covalently modifies c-Jun and directly inhibits the DNA binding activity of AP-1, which may contribute to the complex effects of cyclopentenone prostaglandins on the cellular response to pro-inflammatory agents.