Federica Agosta

TL;DR: The burden of CLs and tissue loss are among the major structural changes associated with cognitive impairment in relapsing-remitting MS.

TL;DR: The extent of the changes suggests that neocortical GM pathology may occur early in the course of the disease in both RR and PP MS patients and contribute significantly to neurologic impairment.

TL;DR: The results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN, which may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity.

TL;DR: A deep learning algorithm is built and validated predicting the individual diagnosis of Alzheimer's disease and mild cognitive impairment who will convert to AD (c-MCI) based on a single cross-sectional brain structural MRI scan, demonstrating that it is exploitable by not-trained operators and likely to be generalizable to unseen patient data.

TL;DR: Quarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers and were associated with increased patients’ neuropsychiatric burden (p<0.0001); health services need to plan a post-pandemic strategy.