Paolo Provero

TL;DR: This study identified and validated endogenous protein-coding transcripts that regulate PTEN, antagonize PI3K/AKT signaling, and possess growth- and tumor-suppressive properties and presents a road map for the prediction and validation of ceRNA activity and networks and thus imparts a trans-regulatory function to protein- coding mRNAs.

TL;DR: In this article, a possible definition of path integrals for string theory is studied, based on a discretized version of Polyakov's generating functional, and the finite resolution of string theory, as opposed to the infinite resolution in particle theory, clearly emerges from a renormalization group type analysis.

TL;DR: The latest version of the BioMart Community Portal comes with many new databases that have been created by the ever-growing community and comes with better support and extensibility for data analysis and visualization tools.

TL;DR: This study genetically identifies multiple putative microRNA decoys for PTEN, validates Z EB2 mRNA as a bona fide PTEN ceRNA, and demonstrates that abrogated ZEB2 expression cooperates with BRAF V600E to promote melanomagenesis.

TL;DR: It is shown that targeted pharmacologic disruption of EZH2 by the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep), or its specific downregulation by short hairpin RNA (shRNA), strongly impairs GBM cancer stem cell (CSC) self-renewal in vitro and tumor-initiating capacity in vivo.