Federica Viti

TL;DR: The Genes-to-Systems Breast Cancer (G2SBC) Database is presented, a resource which integrates data about genes, transcripts and proteins reported in literature as altered in breast cancer cells and provides an ontology based query system and analysis tools related to intracellular pathways, PPIs, protein structure and systems modelling.

TL;DR: A better understanding of the early stage osteogenic differentiation program of MSC seeded on calcium-based biomaterials is required in order to develop optimal strategies to promote osteogenesis through the use of new generation osteoconductive scaffolds.

TL;DR: This work addressed the issue of comparing gene expression profiles from two microarray platforms by devising a standardized investigative strategy and tested this procedure by studying MDA-MB-231 cells, which undergo apoptosis on treatment with resveratrol.

TL;DR: The mechanoreceptors in bone tissue that can feel and process fluid flow are described and an overview of the biological processes and biochemical cascades initiated by fluid shear stress in bone cells is presented.

TL;DR: It is found that plinabulin is more persistently bound to the colchicine site of βII- compared to βIII-tubulin, allowing for a prediction of isotype-expression-dependent drug sensitivity and improving understanding of their mechanism of action, residence time, and tubulin isotype selectivity.