F
Fei-Yu Han
Researcher at McGill University
Publications - 17
Citations - 1032
Fei-Yu Han is an academic researcher from McGill University. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 11, co-authored 17 publications receiving 1003 citations. Previous affiliations of Fei-Yu Han include Montreal General Hospital.
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Journal Article
Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease.
M. H. Ruttledge,Anne Andermann,C. M. Phelan,J. O. Claudio,Fei-Yu Han,N. Chretien,S. Rangaratnam,Mia MacCollin,P. Short,Dilys M. Parry,V. Michels,V. M. Riccardi,R. Weksberg,Ken Kitamura,J. M. Bradburn,Bryan D. Hall,P. Propping,Guy A. Rouleau +17 more
TL;DR: Clinical data provide conclusive evidence that a phenotype/genotype correlation exists for certain NF2 mutations, and when individuals harboring protein-truncating mutations are compared with cases with single codon alterations, a significant correlation with clinical outcome is observed.
Journal Article
Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis.
A Pramatarova,Denise A. Figlewicz,A. Krizus,Fei-Yu Han,I Ceballos-Picot,A. Nicole,M. Dib,Vincent Meininger,Robert H. Brown,Guy A. Rouleau +9 more
TL;DR: The results suggest that SOD 1 mutations are responsible for > or = 13% of FALS cases, and two mutations alter amino acids that have never been implicated in FALS.
Journal ArticleDOI
The human large gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family
Myriam Peyrard,Eyal Seroussi,Ann-Christin Sandberg-Nordqvist,Ya-Gang Xie,Fei-Yu Han,Ingegerd Fransson,Jack R. Collins,Ian Dunham,Maria Kost-Alimova,Stephan Imreh,Jan P. Dumanski +10 more
TL;DR: An abnormal function of the human like-acetylglucosaminyltransferase protein may be linked to the development/progression of meningioma by altering the composition of gangliosides and/or by effect(s) on other glycosylated molecules in tumor cells.
Journal ArticleDOI
Deletions on chromosome 22 in sporadic meningioma
Martin H. Ruttledge,Ya-Gang Xie,Fei-Yu Han,Myriam Peyrard,V. Peter Collins,Magnus Nordenskjöld,Jan P. Dumanski +6 more
TL;DR: The results show that NF2 is completely inactivated in sporadic meningioma but do not rule out the possibility that additional chromosome 22 loci are important in tumorigenesis.
Journal ArticleDOI
Characterization of a new member of the human /-adaptin gene family from chromosome 22q12, a candidate meningioma gene
Myriam Peyrard,Ingegerd Fransson,Ya-Gang Xie,Fei-Yu Han,Martin H. Ruttledge,S. Swahn,John E. Collins,Ian Dunham,Vincent Peter Collins,Jan P. Dumanski +9 more
TL;DR: BAM22 is proposed as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene, and totally inactivated in the tumor with homozygous deletion.