V
Vincent Meininger
Researcher at Pierre-and-Marie-Curie University
Publications - 57
Citations - 3298
Vincent Meininger is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Genome-wide association study. The author has an hindex of 34, co-authored 57 publications receiving 3026 citations. Previous affiliations of Vincent Meininger include Beaumont Hospital & Trinity College, Dublin.
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Journal ArticleDOI
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
Aleksey Shatunov,Kin Y. Mok,Stephen Newhouse,Michael E. Weale,Bradley N. Smith,Caroline Vance,Lauren Johnson,Jan H. Veldink,Michael A van Es,Leonard H. van den Berg,Wim Robberecht,Philip Van Damme,Orla Hardiman,Anne Farmer,Cathryn M. Lewis,Cathryn M. Lewis,Amy W. Butler,Olubunmi Abel,Peter M. Andersen,Isabella Fogh,Vincenzo Silani,Adriano Chiò,Bryan J. Traynor,Judith Melki,Vincent Meininger,John Landers,Peter McGuffin,Jonathan D. Glass,Hardev Pall,P. Nigel Leigh,John Hardy,Robert H. Brown,John Powell,Richard W. Orrell,Karen E. Morrison,Pamela J. Shaw,Christopher Shaw,Ammar Al-Chalabi +37 more
TL;DR: In this paper, the authors found strong evidence of a genetic association of two single nucleotide polymorphisms in a locus on chromosome 9p21.2 with sporadic ALS, in line with previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia.
Journal ArticleDOI
A confirmatory dose-ranging study of riluzole in ALS
Lucette Lacomblez,Gilbert Bensimon,Peter Leigh,P. Guillet,L. Powe,S. Durrleman,J. C. Delumeau,Vincent Meininger +7 more
TL;DR: Riluzole is well tolerated and decreases the risk of death or tracheostomy in ALS patients and is confirmed in a large representative ALS sample over an 18-month period.
Journal ArticleDOI
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
John Landers,Judith Melki,Vincent Meininger,Jonathan D. Glass,Leonard H. van den Berg,Michael A. van Es,Peter C. Sapp,Peter C. Sapp,Paul W.J. van Vught,Diane McKenna-Yasek,Hylke M. Blauw,Ting Jan Cho,Meraida Polak,Lijia Shi,Anne-Marie Wills,Wendy J. Broom,Nicola Ticozzi,Nicola Ticozzi,Vincenzo Silani,Aslihan Ozoguz,Ildefonso Rodriguez-Leyva,Ildefonso Rodriguez-Leyva,Jan H. Veldink,Adrian J. Ivinson,Christiaan G J Saris,Betsy A. Hosler,Alayna Barnes-Nessa,Nicole R. Couture,John H. J. Wokke,Thomas J. Kwiatkowski,Roel A. Ophoff,Roel A. Ophoff,Simon Cronin,Orla Hardiman,Frank P. Diekstra,P. Nigel Leigh,Christopher Shaw,Claire L. Simpson,Valerie K. Hansen,John Powell,Philippe Corcia,François Salachas,Simon Heath,Pilar Galan,Franck Georges,H. Robert Horvitz,Mark Lathrop,Shaun Purcell,Ammar Al-Chalabi,Robert H. Brown,Robert H. Brown +50 more
TL;DR: Findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability.
Journal ArticleDOI
Mutations in FUS cause FALS and SALS in French and French Canadian populations
Veronique V. Belzil,Paul N. Valdmanis,Patrick A. Dion,Hussein Daoud,Edor Kabashi,Anne Noreau,Julie Gauthier,Pascale Hince,Anne Desjarlais,Jean-Pierre Bouchard,Lucette Lacomblez,François Salachas,Pierre-François Pradat,William Camu,Vincent Meininger,Nicolas Dupré,Guy A. Rouleau +16 more
TL;DR: This study identified sporadic patients with mutations in the FUS gene, and the accumulation and description of different genes and mutations helps to develop a more comprehensive picture of the genetic events underlying amyotrophic lateral sclerosis.
Journal ArticleDOI
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
Isabella Fogh,Antonia Ratti,Cinzia Gellera,Kuang Lin,Cinzia Tiloca,Valentina Moskvina,Lucia Corrado,Gianni Sorarù,Cristina Cereda,Stefania Corti,Davide Gentilini,Daniela Calini,Barbara Castellotti,Letizia Mazzini,Giorgia Querin,Stella Gagliardi,Roberto Del Bo,Francesca Luisa Conforti,Gabriele Siciliano,Maurizio Inghilleri,Francesco Saccà,Paolo Bongioanni,Silvana Penco,Massimo Corbo,Sandro Sorbi,Massimiliano Filosto,Alessandra Ferlini,Anna Maria Di Blasio,Stefano Signorini,Aleksey Shatunov,Ashley R. Jones,Pamela J. Shaw,Karen E. Morrison,Karen E. Morrison,Anne Farmer,Philip Van Damme,Wim Robberecht,Adriano Chiò,Bryan J. Traynor,Michael Sendtner,Judith Melki,Vincent Meininger,Orla Hardiman,Peter M. Andersen,Nigel Leigh,Jonathan D. Glass,Daniel J. Overste,Frank P. Diekstra,Jan H. Veldink,Michael A van Es,Christopher Shaw,Michael E. Weale,Cathryn M. Lewis,Julie Williams,Robert H. Brown,John Landers,Nicola Ticozzi,Mauro Ceroni,Elena Pegoraro,Giacomo P. Comi,Sandra D'Alfonso,Leonard H. van den Berg,Franco Taroni,Ammar Al-Chalabi,John Powell,Vincenzo Silani,Vincenzo Brescia Morra,Alessandro Filla,Filosto Massimo,Angela Marsili,Pensato Viviana,Giorgia Puorro,Vincenzo La Bella,Giancarlo Logroscino,Maria Rosaria Monsurrò,Aldo Quattrone,Isabella Laura Simone,Kreshnik B. Ahmeti,Senda Ajroud-Driss,Jennifer Armstrong,Anne Birve,Hylke M. Blauw,Lucie Bruijn,Wenjie Chen,Mary C. Comeau,Simon Cronin,Gkazi Athina Soraya,Josh D. Grab,Ewout J N Groen,Jonathan L. Haines,Scott Heller,Jie Huang,Wu-Yen Hung,James M. Jaworski,Humaira Khan,Carl D. Langefeld,Miranda C. Marion,Russell L. McLaughlin,Jack W. Miller,Gabriele Mora,Margaret A. Pericak-Vance,Evadnie Rampersaud,Nailah Siddique,Teepu Siddique,Bradley N. Smith,Robert L. Sufit,Simon Topp,Caroline Vance,Paul W.J. van Vught,Yi Yang,J.G. Zheng +110 more
TL;DR: The results provide an insight into the genetic structure of sporadic ALS, confirming that common variation contributes to risk and that sufficiently powered studies can identify novel susceptibility loci, and estimated the contribution of common variation to heritability of sporadicALS as ∼12% using a linear mixed model accounting for all SNPs.