F
Feling Robert H R
Researcher at Scripps Research Institute
Publications - 8
Citations - 1359
Feling Robert H R is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Salinispora tropica & Salinosporamide A. The author has an hindex of 5, co-authored 8 publications receiving 1248 citations. Previous affiliations of Feling Robert H R include University of California, San Diego.
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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
Feling Robert H R,Greg O. Buchanan,Tracy J. Mincer,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: The ocean is an overlooked habitat from which to isolate important microorganisms, and the rate of discovery of new biologically active compounds from common soil actino-mycetes has been falling.
Journal ArticleDOI
New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica.
Philip G. Williams,Greg O. Buchanan,Feling Robert H R,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: Data from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1.
Journal ArticleDOI
Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.
Greg O. Buchanan,Philip G. Williams,Feling Robert H R,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A and B, which were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
Journal ArticleDOI
Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora.
Feling Robert H R,Greg O. Buchanan,Tracy J. Mincer,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: The discovery of a major new group of actino-mycetes in marine sediments suggests that the ocean repre-sents an overlooked habitat from which to isolate theseimportant microorganisms as mentioned in this paper.
Journal ArticleDOI
New Cytotoxic Salinosporamides from the Marine Actinomycete Salinispora tropica.
Philip G. Williams,Greg O. Buchanan,Feling Robert H R,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: In this article, an extensive study of the secondary metabolites produced by the obligate marine actinomycete Salinispora tropica (strain CNB-392), the producing microbe of the potent proteasome inhibitor salinosporamide A (1), has led to the isolation of seven related gamma-lactams.