F
Felix T. Wieland
Researcher at Heidelberg University
Publications - 158
Citations - 22192
Felix T. Wieland is an academic researcher from Heidelberg University. The author has contributed to research in topics: COPI & Golgi apparatus. The author has an hindex of 71, co-authored 158 publications receiving 20604 citations. Previous affiliations of Felix T. Wieland include Stanford University.
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Journal ArticleDOI
A Critical Role for Ceramide Synthase 2 in Liver Homeostasis: I. ALTERATIONS IN LIPID METABOLIC PATHWAYS*
Yael Pewzner-Jung,Hyejung Park,Elad L. Laviad,Liana C. Silva,Liana C. Silva,Sujoy Lahiri,Johnny Stiban,Racheli Erez-Roman,Britta Brügger,Timo Sachsenheimer,Felix T. Wieland,Manuel Prieto,Alfred H. Merrill,Anthony H. Futerman +13 more
TL;DR: Results demonstrate novel modes of cross-talk and regulation between the various branches of lipid metabolic pathways upon inhibition of very long acyl chain ceramide synthesis, and differences were observed in the biophysical properties of lipid extracts isolated from liver microsomes.
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A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.
K Sohn,L. Orci,M Ravazzola,M Amherdt,Martina Bremser,F. Lottspeich,Klaus Fiedler,J B Helms,Felix T. Wieland +8 more
TL;DR: Biochemical analysis revealed that p23 is enriched in vesicles by a factor of approximately 20, as compared with the donor Golgi fraction, and is present in amounts stoichiometric to the small GTP-binding protein ADP-ribosylation factor (ARF) and coatomer.
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Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice
Claus Rodemer,Thanh-Phuong Thai,Britta Brügger,Thomas Kaercher,Hauke B. Werner,Klaus-Armin Nave,Felix T. Wieland,Karin Gorgas,Wilhelm W. Just +8 more
TL;DR: Data suggest that the EL-deficient mice allow the identification of new phenotypes not related so far to EL- deficiency and indicate that PLs are required for the correct assembly and function of LRMs.
Journal ArticleDOI
Sphingomyelin is synthesized in the cis Golgi
TL;DR: In vitro a truncated ceramide analogue with 8 carbon atoms in the sphingosine and the fatty acyl residue, each, is employed to investigate the activity of various membrane fractions to synthesize truncated sphingomyelin.
Journal ArticleDOI
Vesicle coats: structure, function, and general principles of assembly
TL;DR: The implications of structural similarities and differences for understanding the function, assembly principles, and evolution of vesicle coats are described.