F
Felix T. Wieland
Researcher at Heidelberg University
Publications - 158
Citations - 22192
Felix T. Wieland is an academic researcher from Heidelberg University. The author has contributed to research in topics: COPI & Golgi apparatus. The author has an hindex of 71, co-authored 158 publications receiving 20604 citations. Previous affiliations of Felix T. Wieland include Stanford University.
Papers
More filters
Journal ArticleDOI
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid
Felix Findeisen,Jürgen U. Linder,Anita Schultz,Joachim E. Schultz,Britta Brügger,Felix T. Wieland,Irmgard Sinning,Ivo Tews +7 more
TL;DR: Structures at acidic and basic pH values are determined and structure-based mutagenesis in the holoenzyme is employed to elucidate regulation using an AC activity assay and the new studies demonstrate that the length of the linker segment is decisive for regulation.
Journal ArticleDOI
Distinct binding sites for the ATPase and substrate-binding domain of human Hsp70 on the cell surface of antigen presenting cells.
Sandra Zitzler,Alice Hellwig,Franz-Ulrich Hartl,Felix T. Wieland,Petra Diestelkötter-Bachert +4 more
TL;DR: The existence of at least two distinct receptors for Hsp70 are established, which are localized to distinct microdomains of the APC membrane, and the interaction of C70 with its putative receptor seems to be responsible for HSp70-mediated cross presentation.
Journal ArticleDOI
Differential transport of Influenza A neuraminidase signal anchor peptides to the plasma membrane
Andreas M. Ernst,Sonja Zacherl,Alexia Herrmann,Moritz Hacke,Walter Nickel,Felix T. Wieland,Britta Brügger +6 more
TL;DR: Stunningly, subtle differences in the primary structure of the part of the transmembrane domain that resides in the exoplasmic leaflet of the membrane have a major impact on transport efficiency, providing a potential target for the inhibition of virus release.
Journal ArticleDOI
Following the Fate In Vivo of COPI Vesicles Generated In Vitro
TL;DR: Fluorescently labeled COPI vesicles were generated in vitro from isolated rat liver Golgi membranes, labeled with the fluorescent dyes Alexa‐488 or Alexa‐568, and appeared to be active and colocalized with endogenous Gol Gi membranes within 30 min after microinjection into mammalian cells.
Journal ArticleDOI
Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity.
Irit Pevzner,Jeroen R.P.M. Strating,Lena Lifshitz,Anna Parnis,Fabian Glaser,Alexia Herrmann,Britta Brügger,Felix T. Wieland,Dan Cassel +8 more
TL;DR: Findings point to a distinct role of each of the two coatomer subcomplexes in the regulation of ArfGAP2‐dependent GTP hydrolysis on Arf1, where the CM4 subcomplex functions in GAP recruitment, while, similarly to the COPII system, the cage‐like CM3 subcomplex stimulates the catalytic reaction.