Feng Gao

TL;DR: A flexible synthesis of a small library of 68Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction allows for a simple and efficient radiosynthetic route to produce a variety of 68 Ga-labeling imaging agents for tumor hypoxia.

TL;DR: A new Ac macrocyclic chelator named 'crown' is reported, which binds quantitatively and rapidly (< 15 min) to Ac at ambient temperature, which demonstrates dramatically different biodistrubution patterns of 225 Ac-crown-αMSH when subjected to different latency times before injection.

TL;DR: A caspase-responsive smart PET probe [18F]1 for detecting the drug-induced apoptosis was fully evaluated in vitro and in vivo and was very stable in both PBS and mouse serum within 4 h.

TL;DR: Two bifunctional chelators are reported to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition to achieve high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

TL;DR: In this article, a series of chelates DOTA-xPy (x = 1−4) were shown to have good stability in human serum up to 24 h and no transmetallation was observed for all three 64Cu complexes.