Cristina Rodríguez-Rodríguez

TL;DR: The fluorescence features of HBX, HBT, BM, and the corresponding iodinated derivatives, together with fluorescence microscopy studies on two types of pregrown fibrils, have shown that HBX and HBT compounds could behave as potential markers for the presence of amyloid fibril buildup and may be especially suitable for radioisotopic detection of Abeta deposits.

TL;DR: The state-of-the-art in this latest strategy for designing metal-ion chelators as potential therapeutic agents in neurodegenerative diseases will be discussed, with special emphasis on AD and additional coverage of PD and prion diseases.

TL;DR: Findings establish macropa to be a highly promising ligand for 225 Ac chelation that will facilitate the clinical development of 225 Ac TAT for the treatment of soft-tissue metastases.

TL;DR: Evidence is given of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically.

TL;DR: The pro-ligands were assessed for their antioxidant activity, cytotoxicity and ability to interfere with metal ion-induced amyloid peptide aggregation to screen promising lead compounds, and 3-(β-D-glucopyranosyloxy)-1-[4-bromophenyl)-2-thiazolyl]-2-methyl-4(1H)-pyridinone ([125I]-GL7) was shown to cross the blood–brain barrier using an