Feride Cengelli

TL;DR: Functionalized aminoPVA-SPIONs represent biocompatible potential vector systems for drug delivery to the brain that may be combined with MRI detection of active lesions in neurodegenerative diseases.

TL;DR: The interactions of biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIO NPs) (iron oxide core 9–10 nm) coated with either cationic polyvinylamine (aminoPVA) or anionic oleic acid with human HT-29 and Caco-2 colon cells was determined.

TL;DR: The present work studied the possibility of developing a versatile synthesis protocol to hierarchically construct drug-functionalized-SPIONs as potential anti-cancer agents and designed and synthesized bifunctional linkers of varied length and chemical composition to which the anti- cancer drugs 5-fluorouridine or doxorubicin were attached as biologically labile esters or peptides.

TL;DR: The anticancer drug camptothecin was covalently linked at the surface of ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) via a linker, allowing drug release by cellular esterases.

TL;DR: AminoUSPIONs can invade tumors and their uptake by human cells induces cell reaction, and they deeply invaded 3D spheroids of human melanoma cells.