Journal ArticleDOI
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs.
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TLDR
The present work studied the possibility of developing a versatile synthesis protocol to hierarchically construct drug-functionalized-SPIONs as potential anti-cancer agents and designed and synthesized bifunctional linkers of varied length and chemical composition to which the anti- cancer drugs 5-fluorouridine or doxorubicin were attached as biologically labile esters or peptides.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2008-03-15. It has received 48 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.read more
Citations
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Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin,Sumit Arora +1 more
TL;DR: This review provides a comprehensive understanding of SPIONs with regard to their method of preparation, their utility as drug delivery vehicles, and some concerns which need to be resolved before they can be moved from bench top to bedside.
Journal ArticleDOI
Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery
Sibnath Kayal,Raju V. Ramanujan +1 more
TL;DR: In this article, the authors showed that DOX loaded PVA coated iron oxide nanoparticles are promising for magnetically targeted drug delivery, and the binding of DOX to the PVA was confirmed by FTIR analysis.
Journal ArticleDOI
Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances.
TL;DR: Tuning the surface chemistry and design of magnetic nanoparticles are described in relation to their applicability in advanced medical technologies and biotechnologies including magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, magnetic separations and immobilizations of proteins, enzymes, antibodies, targeting agents and other biosubstances.
Journal ArticleDOI
Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells
Blanka Halamoda Kenzaoui,Catherine Chapuis Bernasconi,Seher Guney-Ayra,Lucienne Juillerat-Jeanneret +3 more
TL;DR: It is shown that NPs are internalized by human brain-derived endothelial cells; however, the extent of their intracellular uptake is dependent on the characteristics of the NPs.
Journal ArticleDOI
Current Advances in Polymer-Based Nanotheranostics for Cancer Treatment and Diagnosis
Brian T. Luk,Liangfang Zhang +1 more
TL;DR: The use of polymer nanomaterials for drug delivery, gene delivery, and photodynamic therapy, combined with imaging agents for magnetic resonance imaging, radionuclide imaging, and fluorescence imaging, is summarized.
References
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Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Polymer Therapeutics: Concepts and Applications
Rainer Haag,Felix Kratz +1 more
TL;DR: An overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
Journal Article
Locoregional Cancer Treatment with Magnetic Drug Targeting
Christoph Alexiou,Wolfgang Arnold,R. Klein,Fritz G. Parak,P. Hulin,Christian Bergemann,Wolfgang Erhardt,Stefan Wagenpfeil,Andreas S. Lübbe +8 more
TL;DR: This "magnetic drug targeting" offers a unique opportunity to treat malignant tumors locoregionally without systemic toxicity and may be possible to use these magnetic particles as a "carrier system" for a variety of anticancer agents, e.g., radionuclides, cancer-specific antibodies, and genes.
Journal ArticleDOI
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
TL;DR: Whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of nanomaterials is investigated and a parallel synthesis of a library comprising 146 nanoparticles decorated with different synthetic small molecules is described.
Journal Article
Clinical Experiences with Magnetic Drug Targeting: A Phase I Study with 4′-Epidoxorubicin in 14 Patients with Advanced Solid Tumors
Andreas S. Lübbe,Christian Bergemann,Hanno Riess,Folke Schriever,Peter Reichardt,Kurt Possinger,Michael Matthias,Bernd Dörken,Friedhelm Herrmann,Renate Gurtler,Peter Hohenberger,Norbert Haas,Reinhard Sohr,Bernhard Sander,Arne-Jurgen Lemke,Dieter Ohlendorf,Winfried Huhnt,Dieter Huhn +17 more
TL;DR: It was shown that the ferrofluid could be successfully directed to the tumors in about one-half of the patients, and treatment with magnetic drug targeting with epirubicin was well tolerated.
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