F
Fiachra Humphries
Researcher at University of Massachusetts Medical School
Publications - 24
Citations - 993
Fiachra Humphries is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 17 publications receiving 501 citations. Previous affiliations of Fiachra Humphries include National University of Ireland & Maynooth University.
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Journal ArticleDOI
Succination inactivates gasdermin D and blocks pyroptosis
Fiachra Humphries,Liraz Shmuel-Galia,Natália Ketelut-Carneiro,Sheng Li,Bingwei Wang,Venkatesh V. Nemmara,Ruth Wilson,Zhaozhao Jiang,Farnaz Khalighinejad,Khaja Muneeruddin,Scott A. Shaffer,Ranjan Dutta,Carolina Ionete,Scott Pesiridis,Shuo Yang,Paul R. Thompson,Katherine A. Fitzgerald +16 more
TL;DR: In mice, the administration of DMF protects against lipopolysaccharide shock and alleviates familial Mediterranean fever and experimental autoimmune encephalitis by targeting GSDMD, revealing a mechanism of action for fumarate-based therapeutics that include DMF, for the treatment of multiple sclerosis.
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RIP kinases: key decision makers in cell death and innate immunity
TL;DR: This review aims to highlight the importance of the RIP kinase family in controlling various defence strategies, including an inflammatory form of cell death know as necroptosis, and the molecular and functional interplay of RIP1 and RIP3.
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The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
Fiachra Humphries,Ronan Bergin,Ruaidhri Jackson,Nezira Delagic,Bingwei Wang,Shuo Yang,Shuo Yang,Alice V. Dubois,Rebecca J. Ingram,Paul N. Moynagh,Paul N. Moynagh +10 more
TL;DR: A critical function of the E3 ubiquitin ligase Pellino2 is shown in facilitating activation of the NLRP3 inflammasome, which is important for inducing IL-1β and IL-18 inflammatory responses.
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Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
Shuo Yang,Bingwei Wang,Fiachra Humphries,Ruaidhri Jackson,Marc E. Healy,Ronan Bergin,Gabriella Aviello,Barry Hall,Deirdre McNamara,Trevor Darby,Aoife Quinlan,Fergus Shanahan,Silvia Melgar,Padraic G. Fallon,Padraic G. Fallon,Paul N. Moynagh +15 more
TL;DR: It is found that the E3 ubiquitin ligase Pellino3 was an important mediator in the Nod2 signaling pathway and regulator of intestinal inflammation.
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A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Fiachra Humphries,Liraz Shmuel-Galia,Zhaozhao Jiang,Ruth Wilson,Philip S. Landis,Sze-Ling Ng,Krishna-Mohan Parsi,René Maehr,John Cruz,Angel I. Morales-Ramos,Ramanjulu Joshi M,John Bertin,G. Scott Pesiridis,Katherine A. Fitzgerald +13 more
TL;DR: In this article, a diamidobenzimidazole compound, diABZI-4, was used to activate STING and inhibited SARS-CoV-2 replication in lung epithelial cells.