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Natália Ketelut-Carneiro
Researcher at University of Massachusetts Medical School
Publications - 8
Citations - 485
Natália Ketelut-Carneiro is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Paracoccidioides brasiliensis & Innate immune system. The author has an hindex of 5, co-authored 7 publications receiving 206 citations. Previous affiliations of Natália Ketelut-Carneiro include University of São Paulo.
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Journal ArticleDOI
Succination inactivates gasdermin D and blocks pyroptosis
Fiachra Humphries,Liraz Shmuel-Galia,Natália Ketelut-Carneiro,Sheng Li,Bingwei Wang,Venkatesh V. Nemmara,Ruth Wilson,Zhaozhao Jiang,Farnaz Khalighinejad,Khaja Muneeruddin,Scott A. Shaffer,Ranjan Dutta,Carolina Ionete,Scott Pesiridis,Shuo Yang,Paul R. Thompson,Katherine A. Fitzgerald +16 more
TL;DR: In mice, the administration of DMF protects against lipopolysaccharide shock and alleviates familial Mediterranean fever and experimental autoimmune encephalitis by targeting GSDMD, revealing a mechanism of action for fumarate-based therapeutics that include DMF, for the treatment of multiple sclerosis.
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IL-18 Triggered by the Nlrp3 Inflammasome Induces Host Innate Resistance in a Pulmonary Model of Fungal Infection
Natália Ketelut-Carneiro,Grace K. Silva,Fernanda Agostini Rocha,Cristiane M. Milanezi,Florêncio Figueiredo Cavalcanti-Neto,Dario S. Zamboni,João Santana da Silva +6 more
TL;DR: The results show that the Nlrp3 inflammasome is essential for resistance against P. brasiliensis because it orchestrates robust caspase-1 activation and triggers an IL-18–dependent proinflammatory response.
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Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis.
Fabrine Sales Massafera Tristão,Fernanda Agostini Rocha,Daniela Carlos,Natália Ketelut-Carneiro,Camila O S Souza,Cristiane M. Milanezi,João Santana da Silva +6 more
TL;DR: Results suggest that Th17-associated cytokines are involved in the modulation of immune response and granuloma formation during experimental PCM and suggest that IL-6 production by bone marrow-derived macrophages (BMDMs) is important to promote the Th17 differentiation during Pb18 infection.
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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
Liraz Shmuel-Galia,Fiachra Humphries,Xuqiu Lei,Simona Ceglia,Ruth Wilson,Zhaozhao Jiang,Natália Ketelut-Carneiro,Sage E. Foley,Susanne Pechhold,JeanMarie Houghton,Khaja Muneeruddin,Scott A. Shaffer,Beth A. McCormick,Andrea Reboldi,Doyle V. Ward,Ann Marshak-Rothstein,Katherine A. Fitzgerald +16 more
TL;DR: The role of the cGAS-STING DNA-sensing pathway in intestinal inflammation was investigated in mice with colitis and in humans afflicted with inflammatory bowel disease as discussed by the authors.
Journal ArticleDOI
Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis.
Natália Ketelut-Carneiro,Camila O S Souza,Luciana Benevides,Luiz Gustavo Gardinassi,Maria Cláudia Silva,Lucas Alves Tavares,Dario S. Zamboni,João Santana da Silva +7 more
TL;DR: The data suggest that the IFN-β/caspase-11/IL-1α pathway shapes a protective antifungal Th17 immunity, revealing a molecular mechanism underlying the cross-talk between innate and adaptive immunity.