F
Finn Grey
Researcher at University of Edinburgh
Publications - 50
Citations - 1939
Finn Grey is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Viral replication & Gene. The author has an hindex of 20, co-authored 44 publications receiving 1712 citations. Previous affiliations of Finn Grey include University of Cambridge & Oregon Health & Science University.
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Journal ArticleDOI
A Human Cytomegalovirus-Encoded microRNA Regulates Expression of Multiple Viral Genes Involved in Replication
TL;DR: The ability of a viral miRNA to regulate multiple viral genes is demonstrated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121.
Journal ArticleDOI
Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAs
Finn Grey,Andy Antoniewicz,Edwards Allen,Julie A. Saugstad,Andy McShea,James C. Carrington,Jay A. Nelson +6 more
TL;DR: It is demonstrated that human cytomegalovirus encodes multiple conserved miRNAs and suggested that the virus may utilize an miRNA strategy to regulate cellular and viral gene function, and examined the AD169 genome using a bioinformatics approach.
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A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs
Finn Grey,Rebecca Tirabassi,Heather L. Meyers,Guanming Wu,Shannon K. McWeeney,Lauren M. Hook,Jay A. Nelson +6 more
TL;DR: Using RNA induced silencing complex immunoprecipitation techniques, multiple cellular targets for a human cytomegalovirus miRNA are identified, demonstrating that a viral miRNA mediates translational repression of multiple cellular genes by targeting mRNA 5′UTRs.
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Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target.
Valentina Libri,Aleksandra Helwak,Pascal Miesen,Diwakar Santhakumar,Jessica G. Borger,Grzegorz Kudla,Finn Grey,David Tollervey,Amy H. Buck +8 more
TL;DR: This virus–host interaction reveals a mode of miRNA regulation in which a mRNA directs the degradation of a miRNA, and it is speculated that RNA-mediated miRNA degradation could be a more general viral strategy for manipulating host cells.
Journal ArticleDOI
Cytomegalovirus miRNAs Target Secretory Pathway Genes to Facilitate Formation of the Virion Assembly Compartment and Reduce Cytokine Secretion
Lauren M. Hook,Finn Grey,Finn Grey,Robert Grabski,Rebecca Tirabassi,Tracy Doyle,Meaghan H. Hancock,Igor Landais,Sophia Jeng,Shannon K. McWeeney,William J. Britt,Jay A. Nelson +11 more
TL;DR: Observations indicate that multiple HCMV miRNAs coordinately regulate reorganization of the secretory pathway to control cytokine secretion and facilitate formation of the VAC for efficient infectious virus production.