Fiona C. Britton

TL;DR: The fundamental role of ANO1 is demonstrated in the generation of slow waves in GI ICC, which failed to develop by birth in mice homozygous for a null allele of Tmem16a and did not develop subsequent to birth in organ culture, as in wildtype and heterozygous muscles.

TL;DR: Results indicate that PKG activates cslo-α by direct phosphorylation at serine 1072, the α-subunit of the large conductance Ca2+-activated K+ channel, in smooth muscle cells.

TL;DR: This review provides a summary of recent findings demonstrating the regulation of native ClCa channels in vascular smooth muscle cells by calmodulin-dependent protein kinase II and calcineurin and how their fine tuning by these enzymes may influence vascular tone.

TL;DR: Intracellular microelectrode recordings suggest that Tmem16a-encoded CaCCs contribute to membrane potential and are responsible for the upstroke and plateau phases of oviduct slow waves.

TL;DR: Anoctamin 1 is a prominent conductance in ICC, and these channels appear to be involved in pacemaker activity and in responses to enteric excitatory neurotransmitters.