Kate E O'Driscoll

TL;DR: The fundamental role of ANO1 is demonstrated in the generation of slow waves in GI ICC, which failed to develop by birth in mice homozygous for a null allele of Tmem16a and did not develop subsequent to birth in organ culture, as in wildtype and heterozygous muscles.

TL;DR: This review provides a summary of recent findings demonstrating the regulation of native ClCa channels in vascular smooth muscle cells by calmodulin-dependent protein kinase II and calcineurin and how their fine tuning by these enzymes may influence vascular tone.

TL;DR: Interstitial cells of Cajal are tightly associated with excitatory and inhibitory motor neurons in the gastrointestinal tract and these cells are also connected electrically to smooth muscle cells, suggesting that ICC participate in responses to neurotransmitters released from neurons that drive motility and help move nutrients and wastes through the gut.

TL;DR: The hypothesis that the Ca(2+) responsible for the stochastic activation of ANO1 channels during spontaneous transient inward currents (STICs) and synchronized activation of Anoctamin 1 (ANO1) channels during slow wave currents comes from intracellular Ca( 2+) stores is investigated.

TL;DR: The functional and mutational studies examining the biophysical properties of mBest3 indicate that it functions as a pore-forming chloride channel that is activated by physiological levels of calcium.