Florence Dotigny

TL;DR: Using two-photon microscope live imaging, it is demonstrated that retinal pericytes rely on IP-TNTs to control local neurovascular coupling and coordinate light-evoked responses between adjacent capillaries, characterizing their critical role in regulating neurov vascular coupling in the living retina under both physiological and pathological conditions.

TL;DR: It is shown that tau accumulation promotes anterograde axonal transport impairment in vivo, and this response is identified as an early feature of neuronal dysfunction that precedes cell death in the AD retina.

TL;DR: B1R displays a pathological role in the early stage of diabetes by increasing oxidative stress and pro-inflammatory mediators involved in retinal vascular alterations and appears a highly promising novel approach for the treatment of diabetic retinopathy.

TL;DR: A strong involvement of the basal forebrain cholinergic system in the modulation of post-synaptic visual processing, which could be related to cognitive enhancement or attention during visual learning.

TL;DR: It is demonstrated that when coupled with visual training, the cholinergic system improves visual performance for the trained orientation probably through enhancement of attentional processes and cortical plasticity in V1 related to the ratio of excitatory/inhibitory inputs.