F
Florence R. M. Theberge
Researcher at National Institute on Drug Abuse
Publications - 7
Citations - 1310
Florence R. M. Theberge is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Craving & Prefrontal cortex. The author has an hindex of 6, co-authored 7 publications receiving 1122 citations. Previous affiliations of Florence R. M. Theberge include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TL;DR: Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.
Journal ArticleDOI
Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.
Jennifer M. Bossert,Anna L. Stern,Florence R. M. Theberge,Carlo Cifani,Eisuke Koya,Bruce T. Hope,Yavin Shaham +6 more
TL;DR: In a rat model of context-induced relapse to heroin, a small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neurons by drug- associated contexts during abstinence provoked drug relapse.
Journal ArticleDOI
Role of Projections from Ventral Medial Prefrontal Cortex to Nucleus Accumbens Shell in Context-Induced Reinstatement of Heroin Seeking
Jennifer M. Bossert,Anna L. Stern,Florence R. M. Theberge,Nathan J. Marchant,Hui Ling Wang,Marisela Morales,Yavin Shaham +6 more
TL;DR: It is demonstrated that activation of glutamatergic projections from ventral mPFC to accumbens shell, previously implicated in inhibition of cocaine relapse, promotes heroin relapse.
Journal ArticleDOI
Role of Orbitofrontal Cortex Neuronal Ensembles in the Expression of Incubation of Heroin Craving
Sanya Fanous,Evan M. Goldart,Florence R. M. Theberge,Jennifer M. Bossert,Yavin Shaham,Bruce T. Hope +5 more
TL;DR: Results suggest that heroin-cue-activated OFC neuronal ensembles contribute to the expression of incubation of heroin craving.
Journal ArticleDOI
Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving
Florence R. M. Theberge,Xuan Li,Sarita Kambhampati,Charles L. Pickens,Robyn St. Laurent,Jennifer M. Bossert,Michael H. Baumann,Mark R. Hutchinson,Kenner C. Rice,Linda R. Watkins,Yavin Shaham +10 more
TL;DR: A critical role of TLR4 is suggested in the development of incubation of heroin, but not methamphetamine, craving and chronic delivery of (+)-naltrexone via minipumps during the withdrawal phase decreased incubated cue-induced heroin seeking.