Florian Lienert

TL;DR: It is shown that DNA-binding factors locally influence DNA methylation, enabling the identification of active regulatory regions and shows that neuronal and stem-cell methylomes are dependent on each other, as cell-type-specific LMRs are occupied by cell- type-specific transcription factors.

TL;DR: It is demonstrated that proximal sequence elements are both necessary and sufficient for regulating DNA methylation and reveal basic constraints of this regulation.

TL;DR: Functional binding maps for the methyl-CpG-binding domain (MBD) family of proteins reveal methylation-dependent and -independent binding modes and revise current models of DNA methylation readout through MBD proteins.

TL;DR: The dynamics of the transcriptome and an abundant heterochromatic histone modification, dimethylation of histone H3 at lysine 9 (H3K9me2), during neuronal differentiation of embryonic stem cells are reported, which suggests that cellular differentiation entails local rather than global changes in epigenetic repression and transcriptional activity.

TL;DR: DNA accessibility is increased at active promoters and chromosomal regions that are hyperacetylated at H4K16, particularly at the male X chromosome, suggesting that transcriptional dosage compensation is facilitated by permissive chromatin structure.