T
Tim Roloff
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 14
Citations - 2581
Tim Roloff is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Cellular differentiation & Stem cell. The author has an hindex of 12, co-authored 14 publications receiving 2289 citations. Previous affiliations of Tim Roloff include Novartis.
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Journal ArticleDOI
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
Fabio Mohn,Michael Weber,Michael Rebhan,Tim Roloff,Jens Richter,Michael B. Stadler,Miriam Bibel,Dirk Schübeler +7 more
TL;DR: A model how de novo DNA methylation and dynamic switches in Polycomb targets restrict pluripotency and define the developmental potential of progenitor cells is suggested.
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Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
Urszula Brykczynska,Mizue Hisano,Serap Erkek,Liliana Ramos,Edward J Oakeley,Edward J Oakeley,Tim Roloff,Christian Beisel,Dirk Schübeler,Michael B. Stadler,Antoine H.F.M. Peters +10 more
TL;DR: Two modifications important for Trithorax- and Polycomb-mediated gene regulation have methylation-specific distributions at regulatory regions in human spermatozoa, compatible with a role for Polycomb in repressing somatic determinants across generations, potentially in a variegating manner.
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PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
Shany Koren,Linsey Reavie,Joana Pinto Couto,Duvini De Silva,Michael B. Stadler,Michael B. Stadler,Tim Roloff,Adrian Britschgi,Tobias Eichlisberger,Hubertus Kohler,Olulanu H. Aina,Robert D. Cardiff,Mohamed Bentires-Alj +12 more
TL;DR: It is shown that expression of PIK3CAH1047R in lineage-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mechanism involved in the formation of heterogeneous, multi-lineage mammary tumours.
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Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells.
Florian Lienert,Fabio Mohn,Vijay K. Tiwari,Tuncay Baubec,Tim Roloff,Dimos Gaidatzis,Michael B. Stadler,Dirk Schübeler +7 more
TL;DR: The dynamics of the transcriptome and an abundant heterochromatic histone modification, dimethylation of histone H3 at lysine 9 (H3K9me2), during neuronal differentiation of embryonic stem cells are reported, which suggests that cellular differentiation entails local rather than global changes in epigenetic repression and transcriptional activity.
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Polycomb function during oogenesis is required for mouse embryonic development
Eszter Posfai,Rico Kunzmann,Rico Kunzmann,Vincent Brochard,Vincent Brochard,Juliette Salvaing,Juliette Salvaing,Erik Cabuy,Tim Roloff,Zichuan Liu,Mathieu Tardat,Maarten van Lohuizen,Miguel Vidal,Nathalie Beaujean,Nathalie Beaujean,Antoine H.F.M. Peters +15 more
TL;DR: It is shown that Ring1 and Rnf2, components of Polycomb-repressive complex 1 (PRC1), serve redundant transcriptional functions during oogenesis that are essential for proper ZGA, replication and cell cycle progression in early embryos, and development beyond the two-cell stage.