Fotios Mpekris

TL;DR: A mathematical model for tumor growth that takes into account all three types of stresses: growth-induced stress, externally applied stress, and fluid pressure is developed and finds that fluid pressure increases with tumor growth due to increased vascular permeability and lymphatic impairment, and is governed by the microvascular pressure.

TL;DR: It is reported that targeting angiotensin signaling with losartan can reduce extracellular matrix in ovarian tumors and the associated physical barriers that normally hinder drug delivery and efficacy, leading to better anticancer therapeutic effect.

TL;DR: It is found that low doses of antiangiogenic treatment improve immunotherapy when the two treatments are administered sequentially, but that high doses are less efficacious because of excessive vessel pruning and hypoxia.

TL;DR: It is found that metronomic chemotherapy induces functional normalization of tumor blood vessels, resulting in improved tumor perfusion, which enhances the delivery of drugs to solid tumors and alleviates hypoxia.

TL;DR: Evidence is provided that repurposing Pirfenidone could be used as a promising strategy to enhance drug delivery to solid tumors by normalizing the tumor microenvironment by reducing collagen and hyaluronan levels and improving the anti-tumor efficacy of doxorubicin.