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Hadi Tavakoli Nia
Researcher at Boston University
Publications - Â 50
Citations - Â 2805
Hadi Tavakoli Nia is an academic researcher from Boston University. The author has contributed to research in topics: Medicine & Aggrecan. The author has an hindex of 23, co-authored 42 publications receiving 1873 citations. Previous affiliations of Hadi Tavakoli Nia include Harvard University & Sharif University of Technology.
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Journal ArticleDOI
Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy
Giuliano Scarcelli,Giuliano Scarcelli,William J. Polacheck,Hadi Tavakoli Nia,Kripa Patel,Alan J. Grodzinsky,Roger D. Kamm,Seok Hyun Yun,Seok Hyun Yun +8 more
TL;DR: The 3D Brillouin maps obtained of cells in 2D and 3D microenvironments revealed mechanical changes due to cytoskeletal modulation and cell-volume regulation.
Journal ArticleDOI
Physical traits of cancer.
TL;DR: The authors provide a conceptual framework and discuss the origins of these distinct physical traits of cancer and how they enable and synergize with aberrant cancer biology to fuel cancer initiation, progression, immune evasion, and treatment resistance.
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Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy
Joao Incio,Hao Liu,Priya Suboj,Shan M. Chin,Ivy X. Chen,Matthias Pinter,Mei Rosa Ng,Hadi Tavakoli Nia,Jelena Grahovac,Shannon Kao,Suboj Babykutty,Yuhui Huang,Keehoon Jung,Nuh N. Rahbari,Xiaoxing Han,Vikash P. Chauhan,John D. Martin,Julia Kahn,Peigen Huang,Vikram Desphande,James S. Michaelson,Theodoros Michelakos,Cristina R. Ferrone,Raquel Soares,Yves Boucher,Dai Fukumura,Rakesh K. Jain +26 more
TL;DR: It is concluded that cross-talk between adipocytes, TANs, and PSCs exacerbates desmoplasia and promotes tumor progression in obesity and that clinically available antifibrotic/inflammatory agents can improve the treatment response of PDAC in obese hosts.
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Solid stress and elastic energy as measures of tumour mechanopathology
Hadi Tavakoli Nia,Hao Liu,Giorgio Seano,Meenal Datta,Meenal Datta,Dennis Jones,Nuh N. Rahbari,Joao Incio,Vikash P. Chauhan,Keehoon Jung,John D. Martin,Vasileios Askoxylakis,Timothy P. Padera,Dai Fukumura,Yves Boucher,Francis J. Hornicek,Alan J. Grodzinsky,James W. Baish,Lance L. Munn,Rakesh K. Jain +19 more
TL;DR: Two-dimensional spatial mappings of solid stress and the resulting elastic energy in excised or in situ tumours with arbitrary shapes and wide size ranges can be obtained via three distinct and quantitative techniques that rely on the measurement of tissue displacement after disruption of the confining structures.
Journal ArticleDOI
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
Yanxia Zhao,Jinghong Cao,Alexander Melamed,Michael J. Worley,Allison Gockley,Dennis Jones,Hadi Tavakoli Nia,Yanling Zhang,Triantafyllos Stylianopoulos,Ashwin S. Kumar,Ashwin S. Kumar,Fotios Mpekris,Meenal Datta,Yao Sun,Limeng Wu,Xing Gao,Oladapo Yeku,Marcela G. del Carmen,David R. Spriggs,Rakesh K. Jain,Lei Xu +20 more
TL;DR: It is reported that targeting angiotensin signaling with losartan can reduce extracellular matrix in ovarian tumors and the associated physical barriers that normally hinder drug delivery and efficacy, leading to better anticancer therapeutic effect.