F
Francesca Maria Ruggiero
Researcher at University of Bari
Publications - 68
Citations - 7645
Francesca Maria Ruggiero is an academic researcher from University of Bari. The author has contributed to research in topics: Cardiolipin & Mitochondrion. The author has an hindex of 45, co-authored 68 publications receiving 6951 citations. Previous affiliations of Francesca Maria Ruggiero include University of Texas at San Antonio.
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Journal ArticleDOI
Decrease in Mitochondrial Complex I Activity in Ischemic/Reperfused Rat Heart. Involvement of Reactive Oxygen Species and Cardiolipin
Giuseppe Paradies,Giuseppe Petrosillo,Marilva Pistolese,Nicola Di Venosa,Antonio Federici,Francesca Maria Ruggiero +5 more
TL;DR: It is proposed that the defect in complex I activity in ischemic/reperfused rat heart could be ascribed to a ROS-induced cardiolipin damage, which may provide an explanation for some of the factors responsible for myocardial reperfusion injury.
Journal ArticleDOI
Functional role of cardiolipin in mitochondrial bioenergetics.
Giuseppe Paradies,Valeria Paradies,Valentina De Benedictis,Francesca Maria Ruggiero,Giuseppe Petrosillo +4 more
TL;DR: The current understanding of the functional role that cardiolipin plays in several reactions and processes involved in mitochondrial bioenergetics, including the respiratory chain complexes and substrate carrier proteins is discussed.
Journal ArticleDOI
Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria
TL;DR: It is suggested that mitochondrial‐induced ROS production promotes cytochrome c release from mitochondria by a two‐steps process, consisting of the dissociation of this protein from cardiolipin, followed by permeabilization of the outer membrane, probably by interaction with VDAC.
Journal ArticleDOI
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease.
Giuseppe Paradies,Giuseppe Paradies,Giuseppe Petrosillo,Giuseppe Petrosillo,Valeria Paradies,Valeria Paradies,Russel J. Reiter,Russel J. Reiter,Francesca Maria Ruggiero,Francesca Maria Ruggiero +9 more
TL;DR: The role of melatonin in preventing mitochondrial dysfunction and disease is discussed and recently, melatonin was reported to protect the mitochondria from oxidative damage by preventing cardiolipin oxidation and this may explain the beneficial effect of this molecule in mitochondrial physiopathology.
Journal ArticleDOI
Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage.
TL;DR: It is demonstrated that ROS affect the mitochondrial complex I activity via oxidative damage of cardiolipin which is required for the functioning of this multisubunit enzyme complex.