F
Francesco Fiorentino
Researcher at University of Sassari
Publications - 71
Citations - 2930
Francesco Fiorentino is an academic researcher from University of Sassari. The author has contributed to research in topics: Preimplantation genetic diagnosis & Aneuploidy. The author has an hindex of 26, co-authored 64 publications receiving 2292 citations. Previous affiliations of Francesco Fiorentino include Temple University & University of Palermo.
Papers
More filters
Journal ArticleDOI
Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts
TL;DR: Implantation of 18 mosaic aneuploid blastocysts obtained through in vitro fertilization into 18 women resulted in six pregnancies of normal karyotype, with the birth of six healthy babies.
Journal ArticleDOI
Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study
Maria Giulia Minasi,Alessandro Colasante,Teresa Riccio,Alessandra Ruberti,Valentina Casciani,Filomena Scarselli,Francesca Spinella,Francesco Fiorentino,Maria Teresa Varricchio,Ermanno Greco +9 more
TL;DR: Correlations were observed, in that euploid human blastocysts showed a higher percentage with top quality inner cell mass (ICM) and trophectoderm (TE), higher expansion grades and shorter time to start of blastulation, expansion and hatching, compared to aneuploid ones.
Journal ArticleDOI
PGD for reciprocal and Robertsonian translocations using array comparative genomic hybridization
Francesco Fiorentino,Letizia Spizzichino,Sara Bono,Anil Biricik,Georgia Kokkali,Laura Rienzi,Filippo Ubaldi,E. Iammarrone,A. Gordon,K. Pantos +9 more
TL;DR: The data obtained demonstrate that array-CGH can detect chromosome imbalances in embryos, also providing the added benefit of simultaneous aneuploidy screening of all 24 chromosomes.
Journal ArticleDOI
Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos
Francesco Fiorentino,Anil Biricik,Sara Bono,Letizia Spizzichino,Ettore Cotroneo,Giuliano Cottone,Felix Kokocinski,Claude-Edouard Michel +7 more
TL;DR: This is the first study reporting extensive preclinical validation and accuracy assessment of NGS-based comprehensive aneuploidy screening on single cells, and NGS has demonstrated a robust high-throughput methodology ready for clinical application in reproductive medicine, with potential advantages of reduced costs and enhanced precision.
Journal ArticleDOI
Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development
Antonio Capalbo,Sara Bono,Letizia Spizzichino,Anil Biricik,M. Baldi,Silvia Colamaria,Filippo Maria Ubaldi,Laura Rienzi,Francesco Fiorentino +8 more
TL;DR: Testing at the polar body (PB) stage was the least accurate mainly due to the high incidence of post-zygotic events, suggesting that postponing the time of biopsy to the blastocyst stage of preimplantation embryo development may provide the most reliable results for PGS.