F
Francesca Spinella
Researcher at University of Naples Federico II
Publications - 75
Citations - 4332
Francesca Spinella is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Angiogenesis & Ovarian carcinoma. The author has an hindex of 36, co-authored 75 publications receiving 3805 citations. Previous affiliations of Francesca Spinella include National Research Council.
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Journal ArticleDOI
Endothelin 1 in cancer: biological implications and therapeutic opportunities.
TL;DR: The advances in the understanding of the diverse biological roles of ET1 are discussed and the latest preclinical and clinical progress that has been made using small-molecule antagonists ofET1 receptors that inhibit ET1-driven signalling are described.
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Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study
Maria Giulia Minasi,Alessandro Colasante,Teresa Riccio,Alessandra Ruberti,Valentina Casciani,Filomena Scarselli,Francesca Spinella,Francesco Fiorentino,Maria Teresa Varricchio,Ermanno Greco +9 more
TL;DR: Correlations were observed, in that euploid human blastocysts showed a higher percentage with top quality inner cell mass (ICM) and trophectoderm (TE), higher expansion grades and shorter time to start of blastulation, expansion and hatching, compared to aneuploid ones.
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Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1α in Ovarian Carcinoma Cells *
TL;DR: The results suggest that new therapeutic strategies using specific ETAR antagonists could provide an additional approach to the treatment of ovarian carcinoma by inhibiting neovascularization as well as tumor cell growth, and provide a mechanism whereby ET-1 acting selectively through ETAR can interact with the HIF-1α-dependent machinery of angiogenesis.
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Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells
Laura Rosanò,Roberta Cianfrocca,Francesca Spinella,Valeriana Di Castro,Maria Rita Nicotra,Alessandro Lucidi,Gabriella Ferrandina,Pier Giorgio Natali,Anna Bagnato +8 more
TL;DR: The data provide the first evidence that blockade of ETAR-driven EMT can overcome chemoresistance and inhibit tumor progression, improving the outcome of EOC patients' treatment.
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Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
Laura Rosanò,Francesca Spinella,Valeriana Di Castro,Maria Rita Nicotra,Shoukat Dedhar,Antonio García de Herreros,Pier Giorgio Natali,Anna Bagnato +7 more
TL;DR: It is shown that the ET-1/ET(A)R autocrine pathway drives epithelial-to-mesenchymal transition (EMT) in ovarian tumor cells by inducing a fibroblastoid and invasive phenotype, down-regulation of E-cadherin, increased levels of beta-catenin, Snail, and other mesenchymic markers, and suppression of E/E/R promoter activity.