F
Francesco Latrofa
Researcher at University of Pisa
Publications - 82
Citations - 2935
Francesco Latrofa is an academic researcher from University of Pisa. The author has contributed to research in topics: Thyroid & Thyroglobulin. The author has an hindex of 26, co-authored 67 publications receiving 2253 citations. Previous affiliations of Francesco Latrofa include World Health Organization & University of California, Los Angeles.
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Journal ArticleDOI
Thyroid Stimulation Does Not Require Antibodies with Identical Epitopes But Does Involve Recognition of a Critical Conformation at the N Terminus of the Thyrotropin Receptor A-Subunit
TL;DR: Evidence is provided that TSAb need not have identical epitopes, however, the TSAb epitope does appear to require involvement of the highly conformational N terminus of the A-subunit.
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The Detection of Serum IgMs to Thyroglobulin in Subacute Thyroiditis Suggests a Protective Role of IgMs in Thyroid Autoimmunity
Debora Ricci,Alessandro Brancatella,Michele Marinò,Mario Rotondi,Luca Chiovato,Paolo Vitti,Francesco Latrofa +6 more
TL;DR: Tg leak associated with thyroid injury induces the production of specific TgAb-IgM, which in turn, increasing the clearance of Tg, might prevent the establishment of a persistent thyroid autoimmune response.
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Thyroglobulin autoantibodies of patients with subacute thyroiditis are restricted to a major B cell epitope
Francesco Latrofa,Debora Ricci,Lucia Montanelli,Ma Altea,Andrea Pucci,Aldo Pinchera,Paolo Vitti +6 more
TL;DR: The epitope pattern of TgAb of SAT is restricted to the A region that is immunodominant in AITD and non-AITD, indicating that in the majority of patients with SAT, the autoimmune phenomena represent a non-specific and transient response to the release of thyroid antigens, rather than the expression of thyroid autoimmunity.
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Compared with classic Hashimoto's thyroiditis, chronic autoimmune serum-negative thyroiditis requires a lower substitution dose of L-thyroxine to correct hypothyroidism.
Laura Croce,L. De Martinis,Sara M. A. Pinto,Francesca Coperchini,G. Dito,Giulia Bendotti,Daniela Pasquali,Carlo Cappelli,Francesco Latrofa,Flavia Magri,Luca Chiovato,Mario Rotondi +11 more
TL;DR: Multivariate analysis showed that age, BMI, basal TSH and thyroid antibody status independently and significantly predicted the maximum daily substitution dose of LT4 in SN-CAT patients as compared with the CHT ones.
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Fifty Years After the First Description, MEN 2B Syndrome Diagnosis Is Still Late: Descriptions of Two Recent Cases
Rossella Elisei,Antonio Matrone,Laura Valerio,Eleonora Molinaro,Laura Agate,Valeria Bottici,David Viola,Carlotta Giani,Virginia Cappagli,Francesco Latrofa,Gabriele Materazzi,Liborio Torregrossa,Clara Ugolini,Fulvio Basolo,Cristina Romei +14 more
TL;DR: Two cases of MEN 2B that were diagnosed too late, preventing a cure show that knowledge of this syndrome is still insufficient and that the lack of knowledge impairs the ability to obtain an early diagnosis and cure.