Francesco Paolo Di Giorgio

TL;DR: High-content chemical screening is used to identify small molecules that can replace Sox2 in reprogramming and it is found that one of these molecules functions inReprogramming by inhibiting Tgf-beta signaling in a stable and trapped intermediate cell type that forms during the process.

TL;DR: The studies demonstrate that glial cells carrying a human SOD1G93A mutation have a direct, non–cell autonomous effect on motor neuron survival and show that ESC-based models of disease provide a powerful tool for studying the mechanisms of neural degeneration.

TL;DR: It is shown that human spinal motor neurons, but not interneurons, are selectively sensitive to the toxic effect of glial cells carrying an ALS-causing mutation in the SOD1 gene, demonstrating the relevance of these non-cell-autonomous effects to human motor neurons.

TL;DR: Evidence is presented that iPS cells generated from adult cells can contribute to a chimera's germline is compelling in contrast with the germline-competent reprogramming of embryonic fibroblasts shown by other groups, but it remains to be demonstrated whether terminally differentiated cells can be reprogrammed in this fashion.

TL;DR: In this article , a pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice.