J
Joel W. Blanchard
Researcher at Picower Institute for Learning and Memory
Publications - 23
Citations - 1647
Joel W. Blanchard is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 9, co-authored 20 publications receiving 1323 citations. Previous affiliations of Joel W. Blanchard include Harvard University & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
Justin K. Ichida,Joel W. Blanchard,Kelvin Lam,Esther Y. Son,Julia E. Chung,Dieter Egli,Kyle M. Loh,Ava C. Carter,Francesco Paolo Di Giorgio,Kathryn Koszka,Danwei Huangfu,Hidenori Akutsu,David R. Liu,Lee L. Rubin,Kevin Eggan +14 more
TL;DR: High-content chemical screening is used to identify small molecules that can replace Sox2 in reprogramming and it is found that one of these molecules functions inReprogramming by inhibiting Tgf-beta signaling in a stable and trapped intermediate cell type that forms during the process.
Journal ArticleDOI
Selective conversion of fibroblasts into peripheral sensory neurons
Joel W. Blanchard,Kevin Eade,Attila Szűcs,Valentina Lo Sardo,Rachel K Tsunemoto,Daniel Williams,Pietro Paolo Sanna,Kristin K. Baldwin +7 more
TL;DR: It is found that transiently coexpressing Brn3a with either Ngn1 or Ngn2 selectively reprogrammed human and mouse fibroblasts to acquire key properties of these three classes of sensory neurons, including selective expression of Trk receptors.
Journal ArticleDOI
Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.
Joel W. Blanchard,Michael Bula,Michael Bula,Jose Davila-Velderrain,Leyla Anne Akay,Leyla Anne Akay,Lena Zhu,Lena Zhu,Alexander Frank,Alexander Frank,Matheus B. Victor,Matheus B. Victor,Julia Maeve Bonner,Julia Maeve Bonner,Hansruedi Mathys,Hansruedi Mathys,Hansruedi Mathys,Yuan-Ta Lin,Yuan-Ta Lin,Tak Ko,David A. Bennett,Hugh P. Cam,Hugh P. Cam,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: An iPSC-based three-dimensional model of the human blood–brain barrier reveals that NFAT and APOE dysregulation in pericyte-like mural cells contributes to cerebral amyloid angiopathy and can potentially be targeted to treat Alzheimer’s disease.
Patent
Efficient induction of pluripotent stem cells using small molecule compounds
TL;DR: In this paper, a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated cell was described.
Journal ArticleDOI
Diverse reprogramming codes for neuronal identity
Rachel K Tsunemoto,Rachel K Tsunemoto,Sohyon Lee,Attila Szűcs,Attila Szűcs,Pavel Chubukov,Irina Sokolova,Joel W. Blanchard,Kevin Eade,Jacob Bruggemann,Chunlei Wu,Ali Torkamani,Pietro Paolo Sanna,Kristin K. Baldwin,Kristin K. Baldwin +14 more
TL;DR: A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties and delineates cell-autonomous features of neuronal identity and diversity.