Francesco Pistillo

TL;DR: Some recent findings concerning the structure and function of native nAChRs are reviewed, focussing on the subtypes identified in the rodent habenulo-interpeduncular pathway, a pathway involved in nicotine reinforcement and withdrawal.

TL;DR: This work reviews what is known of the processes regulating nAChR assembly, degradation and trafficking, and how nicotine-induced modulation of these processes leads to nA ChR up-regulation and changes in downstream neuronal plasticity at molecular, cellular and circuit level.

TL;DR: This review provides an updated overview of the circuitry of the ventral tegmental area, ventral striatum and prefrontal cortex, the neurotransmitter receptor subtypes expressed in these areas, and their physiological role in the mesocorticolimbic system.

TL;DR: This study represents the first direct confirmation of α7β2-nAChR expression in human and mouse forebrain, supporting previous mouse studies that suggested relevance of β2 subunit–specific α7α7/α7 subunit interface sites in Alzheimer disease etiopathogenesis.

TL;DR: Results show that nicotine has an area-specific effect on receptor subtypes, regardless of its administration route, but the effect is quantitatively greater in the case of MP administration.