Journal ArticleDOI
Diversity of native nicotinic receptor subtypes in mammalian brain.
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TLDR
Some recent findings concerning the structure and function of native nAChRs are reviewed, focussing on the subtypes identified in the rodent habenulo-interpeduncular pathway, a pathway involved in nicotine reinforcement and withdrawal.About:
This article is published in Neuropharmacology.The article was published on 2015-09-01. It has received 213 citations till now. The article focuses on the topics: Nicotinic acetylcholine receptor & Nicotinic agonist.read more
Citations
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Journal ArticleDOI
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.
Arpiar Saunders,Arpiar Saunders,Evan Z. Macosko,Evan Z. Macosko,Alec Wysoker,Alec Wysoker,Melissa Goldman,Melissa Goldman,Fenna M. Krienen,Fenna M. Krienen,Heather de Rivera,Heather de Rivera,Elizabeth Bien,Elizabeth Bien,Matthew A. Baum,Matthew A. Baum,Laura Bortolin,Laura Bortolin,Shuyu Wang,Aleksandrina Goeva,James Nemesh,James Nemesh,Nolan Kamitaki,Nolan Kamitaki,Sara A. Brumbaugh,Sara A. Brumbaugh,David Kulp,David Kulp,Steven A. McCarroll,Steven A. McCarroll +29 more
TL;DR: Features of brain organization are revealed, including a gene-expression module for synthesizing axonal and presynaptic components, patterns in the co-deployment of voltage-gated ion channels, functional distinctions among the cells of the vasculature and specialization of glutamatergic neurons across cortical regions.
Journal ArticleDOI
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection.
TL;DR: A profound insight is provided into the role of the α7 nAChR subtype in microglia and point out to microglial α7/HO-1 pathway as an anti-inflammatory therapeutic target.
Book ChapterDOI
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine
TL;DR: This review briefly examines the structural and functional properties of the receptor/channel complex itself and summarizes activation and desensitization of nAChRs by the low nicotine concentrations obtained from tobacco.
Journal ArticleDOI
Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
TL;DR: The bulk of evidence highlights the link between cholinergic alterations and PD motor symptoms, gait dysfunction, levodopa-induced dyskinesias, cognitive deterioration, psychosis, sleep abnormalities, autonomic dysfunction, and altered olfactory function and the clinical usefulness of antimuscarinic drugs and inhibitors of the enzyme acetylcholinesterase for the treatment of dementia.
Journal ArticleDOI
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors.
TL;DR: The aim of this review is to describe the most recent findings concerning the structure and function of native nAChRs inside and outside the nervous system.
References
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Journal ArticleDOI
Mammalian nicotinic acetylcholine receptors: from structure to function.
TL;DR: This review provides a comprehensive overview of the advancement of functional and genetic studies in the late 1980s and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body.
Journal ArticleDOI
Metabolism and Disposition Kinetics of Nicotine
TL;DR: Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed.
Journal ArticleDOI
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
John A. Dani,Daniel Bertrand +1 more
TL;DR: Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics.
Journal ArticleDOI
Lateral habenula as a source of negative reward signals in dopamine neurons
TL;DR: It is shown that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward-related signals in dopamine neurons, and the inhibitory input from the lateral ha benula plays an important role in determining the reward- related activity of dopamine neurons.
Journal ArticleDOI
Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
Etsuko Wada,Keiji Wada,Jim Boulter,Evan S. Deneris,Steve Heinemann,Jim Patrick,Larry W. Swanson +6 more
TL;DR: Nine different [35S]‐complementary ribonucleic acid (cRNA) probes were used in the present study to map the distribution of these nAChR subunit mRNAs throughout the central nervous system (CNS) of the rat.
Related Papers (5)
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
John A. Dani,Daniel Bertrand +1 more